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EC number: 212-783-8 | CAS number: 868-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (no GLP study, no environmental conditions reported, body weights not recorded, fasting period too short). However, according to OECD SIDS a reliability of 1 was given.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology and carcinogenesis studies of dimethyl hydrogen phosphite (CAS No. 868-85-9) in F344/N rats and B6C3F1 mice (gavage studies)
- Author:
- National Toxicology Program (NTP)
- Year:
- 1 985
- Bibliographic source:
- Technical Report Series No. 287, NIH Publication, No. 86-2543, 1 - 179
- Reference Type:
- secondary source
- Title:
- Dimethyl phosphonate - CAS No: 868-85-9 - SIDS Initial Assessment Report.
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (no GLP study, no environmental conditions reported, body weights not recorded).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl phosphonate
- EC Number:
- 212-783-8
- EC Name:
- Dimethyl phosphonate
- Cas Number:
- 868-85-9
- Molecular formula:
- C2H7O3P
- IUPAC Name:
- dimethyl phosphonate
- Details on test material:
- - Name of test material (as cited in study report): dimethyl hydrogen phosphite
- Analytical purity: 96%
- Lot/batch No.: DM113077
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories (Portage, MI, USA)
- Age at study initiation: 6 weeks.
- Fasting period before study: yes. Rats were fasted overnight before dosing.
- Housing: 5 animals per cage. Cage: Polycarbonate (Lab Products, Inc., Garfield, NJ, USA).
- Diet (e.g. ad libitum): Purina Lab Chow meal (St. Louis, MO, USA); available ad libitum (except during fasting period).
- Water (e.g. ad libitum): Acidified with HCl (pH 2.6) tap water; available ad libitum.
- Acclimation period: 2 weeks.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 259.03, 378.85, 556.82, 817.62, 1200.00 mg/mL
- Justification for choice of vehicle: the vehicle was chosen because of the potential of the test substance for chemical hydrolysis in water.
- Amount of vehicle (if gavage): 5.675 mL/kg
MAXIMUM DOSE VOLUME APPLIED: 5.675 mL/kg bw
DOSAGE PREPARATION: Appropriate amounts of dimethyl hydrogen phosphite and corn oil were added by pipette to test tube; mixture was shaken for 1 min; mixtures were resuspended before dosing. - Doses:
- 1470, 2150, 3160, 4640, 6810 mg/kg bw.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: observed immediately after dosing, 1 h and 4 h later, and 1 X d thereafter for 14 d.
- Necropsy of survivors performed: yes.
- Other examinations performed: clinical signs, necropsy. - Statistics:
- The LD50 values as determined by the Spearman-Karber method (Finney, 1978. Statistical Method in Biological Assay, 3rd ed. New York: MacMillan
Publishing Co, pp. 394-401).
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 283 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 729 - 3 949
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 040 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 527 - 3 656
- Mortality:
- Number of deaths among male animals at each dose:
- 1470 mg/kg bw: 0/5
- 2150 mg/kg bw: 0/5
- 3160 mg/kg bw : 2/5
- 4640 mg/kg bw : 5/5
- 6810 mg/kg bw : 5/5
Number of deaths among female animals at each dose:
- 1470 mg/kg bw: 0/5
- 2150 mg/kg bw: 0/5
- 3160 mg/kg bw: 3/5
- 4640 mg/kg bw: 5/5
- 6810 mg/kg bw: 5/5 - Clinical signs:
- other: At dose >= 3160 mg/kg bw the following symtomps were observed: inactivity, weakness, shallow breathing.
- Gross pathology:
- No data
- Other findings:
- - Other observations: at a dose >= 3160 mg/kg bw: gas was found in the stomach and/or intestine.
Any other information on results incl. tables
Table 1. Survival of rats in the single-administration gavage studies of dimethyl hydrogen phosphite (a)
Dose (mg/kg) | Survival (b) | |
MALE | ||
1470 | 5/5 | |
2150 | 5/5 | |
3160 | 3/5 | |
4640 | 0/5 | |
6810 | 0/5 | |
FEMALE | ||
1470 | 5/5 | |
2170 | 5/5 | |
3160 | 2/5 | |
4640 | 0/5 | |
6810 | 0/5 |
(a) Body weights were not recorded.
(b) Number surviving/number initially in the group; all deaths occurred on day 1.
Based on the study results and according to DSD-DPD and CLP classification criteria, the test substance is not to be classified.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The oral LD50 of dimethyl phosphonate was determined by acute oral toxicity study conducted with a method similar to OECD guideline 401 with deviations (no GLP study, environmental conditions not reported; body weights not recorded; fasting period too short). The LD50 of dimethyl phosphonate was calculated to be 3040 mg/kg bw in female Fischer 344 rats (95% confidence limits of 2627-3656 mg/kg) and 3283 mg/kg bw in male rats (95% confidence limits of 2729-3949 mg/kg). Clinical signs of toxicity, which have been observed after oral administration of dimethyl phosphonate, were inactivity, weakness, prostration and shallow breathing in rats. Based on the study results, the test substance is not to be classified.
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