Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-783-8 | CAS number: 868-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-validated test system.
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Ashby J, Paton D (1993) The influence of chemical structure|on the extent and sites of carcinogenesis for 522 rodent|carcinogens and 55 different human carcinogen. Mutat Res|286: 3-74 (abstract)
- Title:
- No information
- Author:
- Ashby J, Tennant R (1988) Chemical structure, Salmonella|mutagenicity and extent of carcinogenicity as indicators of|genotoxic carcinogenesis among 222 chemicals tested in|rodents by the U.S: NCI/NTP. Mutat Res 204: 17 - 115
- Title:
- No information
- Author:
- Ashby J, Tennant R (1991) Definitive relationships among|chemical structure, carcinogenicity and mutagenicity for 301|chemicals tested by the U.S. NTP. Mutat Res 257: 229 - 306
- Title:
- No information
- Author:
- Bakale G, McCreary R (1992) Response of the ke test to|NCI/NTP-screened chemicals. II. Genotoxic carcinogens and|non-genotoxic non-carcinogens. Carcinogenesis 13(8): 1437 -|1445
- Title:
- No information
- Author:
- Benigni R (1990) Rodent tumor profiles, Salmonella|mutagenicity and risk assessment. Mutat Res 244: 79 - 91
- Title:
- No information
- Author:
- Gold LS, Slone TH, Stern BR, Bernstein L (1993) Comparison|of target organs of carcinogenicity for mutagenic and|non-mutagenic chemicals. Mutat Res 286: 75 - 100
Materials and methods
- Type of study / information:
- Correlation of structure, mutagenicity and carcinogenicity.
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl phosphonate
- EC Number:
- 212-783-8
- EC Name:
- Dimethyl phosphonate
- Cas Number:
- 868-85-9
- Molecular formula:
- C2H7O3P
- IUPAC Name:
- dimethyl phosphonate
Constituent 1
Results and discussion
Any other information on results incl. tables
NTP/NCI Carcinogens were clustered. DMP was put in Cluster 2 with clear evidence to induce lung and stomach cancer in male rats. The Ames test result of DMP is positive (50% of Cluster 2 Carcinogens had a positive Ames test result and 50 % a negative result). DMP is classified as a mutagenic substance. DMP is put in Group B: Agents found to be carcinogenic to only a single species but to be active at 2 or more sites in that species.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.