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Diss Factsheets
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EC number: 203-475-4 | CAS number: 107-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (report not available for submitter, no further details available)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl vinyl ether
- EC Number:
- 203-475-4
- EC Name:
- Methyl vinyl ether
- Cas Number:
- 107-25-5
- Molecular formula:
- C3H6O
- IUPAC Name:
- methoxyethene
- Details on test material:
- methyl vinyl ether (MVE)
no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were 52 days old at the time of exposure. Rats were identified by toe clipping, and were housed 5 per cage. Animals were kept in rooms designed to maintain adequate environmental conditions, and were given a commercial diet and municipal water ad libitum.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- other: presumably whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- The target chamber concentration was 19,500 ppm (47 mg/L), 75% of the lower explosive limit for MVE. Chamber concentration was analyzed by gas chromatography 27 times during the 4-hour exposure. Nominal concentration was also calculated based on test material used and chamber airflow. Relative humidity and temperature of the chamber were recorded during the exposure.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- (analyzed by gas chromatography)
- Duration of exposure:
- 4 h
- Concentrations:
- 20165 ppm (analytical) or 48 mg/L
- No. of animals per sex per dose:
- 5
- Details on study design:
- Animals were observed for 14 days following the vapor exposure. Body weights were taken pre-exposure, and on days 7 and 14. Gross pathology was performed on all animals. Five male and five female Sprague-Dawley rats were used for the study.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 48 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: original value: 20165 ppm
- Mortality:
- no
- Clinical signs:
- other: no
- Body weight:
- no data on results
- Gross pathology:
- no effects
Any other information on results incl. tables
The analytical concentration of MVE in the chamber was 20,
165 ppm. Temperature and relative humidity of the chamber
was maintained adequately for the species.
There were no clinical signs of toxicity noted on the day of
exposure or during the 14 day post-exposure period. There
was likewise no treatment-related mortality during the 14
day period, and no macroscopic findings noted at necropsy.
The LC50 was > 20,165 ppm.
Applicant's summary and conclusion
- Conclusions:
- No mortality and no clinical signs in rats exposed for 4 h to 20165 ppm (48 mg/L) in a acute inhalation toxicity study; LC50>48 mg/L.
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