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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientific acceptable and sufficient documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Small cellulose lobes (2.5 x 2.5 cm²) with 500 µl of tert-butylisocyanate was applied to the inner surface of one ear per animal; exposure time was 1hour. The test-substance was fixed by a plaster. The post exposure observation time was 7 days.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
tert-butyl isocyanate
EC Number:
216-544-9
EC Name:
tert-butyl isocyanate
Cas Number:
1609-86-5
Molecular formula:
C5H9NO
IUPAC Name:
2-isocyanato-2-methylpropane
Details on test material:
Test substance: tert-butyl isocyanate

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
1 hour(s)
Observation period:
7 days
Number of animals:
1

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48 h
Score:
2.5
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 5, 6, 7 days
Score:
4
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48 h
Score:
1.5
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 5, 6, 7 days
Score:
2.7
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Other effects:
Scurf was observed at the reading after at 1 and 24 hours

Any other information on results incl. tables

A strong erythema and edema was observed until the end of the post-exposure period. Tert-butylisocyanate is strong irritating/corrosive at the inside of a rabbit ear after an application time of 1 hour

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

Small cellulose lobes (2.5 x 2.5 cm²) with 500 µl of tert-butylisocyanate was applied to the inner surface of one ear per animal; exposure time was 1hour. The test-substance was fixed by a plaster. The post exposure observation time was 7 days.

Scurf was observed at the reading after at 1 and 24 hours. A strong erythema and edema was observed until the end of the post-exposure period. Tert-butylisocyanate is strong irritating/corrosive at the inside of a rabbit ear after an application time of 1 hour.