Registration Dossier
Registration Dossier
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EC number: 214-730-4 | CAS number: 1191-16-8
Endpoint summary
Administrative data
Description of key information
- Skin irritation (rabbit, similar to the OECD TG 404): not irritating (TSCATS, 1978)
- Eye irritation (rabbit, similar to the OECD TG 405): not irritating (TSCATS, 1978)
Key value for chemical safety assessment
Additional information
There are valid data available for the assessment of the skin and eye irritation potential of prenyl acetate.
Skin irritation:
In the chosen key study, the ability of prenyl acetate to cause skin irritation / corrosion was assessed in a test protocol similar to the OECD TG 404 (deviations: occlusive treatment, 24 h treatment, no 48 h scoring, only 72 h observation period). Unchanged test substance (0.5 mL) was applied to clipped skin sites of New Zealand White rabbit under occlusive conditions, and the skin reactions were subsequently evaluated 24 and 72 hours thereafter according to the Draize scoring system (TSCATS, 1978). No signs of skin irritation (erythema / edema) were observed 24 and 72 hours after treatment. The respective scores were 0. Therefore, prenyl acetate was found to be non-irritating to skin under the test conditions chosen. In a supporting study, 3% prenyl acetate showed no skin irritation (IFF 1971).
Eye irritation:
In the chosen key study, an eye irritation study performed similar to the OECD Guideline 405, 0.1 mL of undiluted prenyl acetate was applied to the eyes of 9 male Vienna White rabbits (TSCATS, 1978). The test substance was washed out after 20-30 seconds in 3/9 animals (not used for further assessment) and not washed out in 6/9 animals. Evaluation of the irritation reaction was performed 24 h, 48 h, 72 h, 4 days and 7 days after treatment according to the Draize scoring system. Following reactions were observed animals without washing out prenyl acetate: slight corneal opacity (score 1) in 3/6 animals 24 h after treatment, but reversible within 48 hours; no iritis, no conjunctival redness an no chemosis in any test animal at any observation time point was observed. Based on these results, prenyl acetate does not cause eye irritation under the chosen testing conditions. In a supporting study, 3% prenyl acetate showed no evident eye irritation (IFF 1971).
Respiratory irritation:
There are no data available concerning the irritating potential to the respiratory system.
Justification for classification or non-classification
The present data on skin and eye irritation do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
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