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Diss Factsheets
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EC number: 218-059-8 | CAS number: 2044-64-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable for reliability but not in detail documented. Study report meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Litchfield and Wilcoxan method.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acetoacetdimethylamide
- IUPAC Name:
- Acetoacetdimethylamide
- Test material form:
- solid - liquid: suspension
- Details on test material:
- Test item name: Acetoacetdimethylamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Rats:
----
Female Wistar rats weighing 200 +- 20 g. These animals were housed in grid-floor cages under natural lighting conditions with the ambient temperature maintained at 22°C.
Mice:
----
Tylers original strain weighing 20 +- 2 g. These animals were housed in solid floor polycarbonate boxes under natural lighting conditions and maintained at 22°C.
Rabbits:
-------
New Zealand White does weighing 2.0 +- 0.2 kg. All animals were caged individually under natural lighting conditions maintained at 22°C.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water and 0.5% aqueous solution of Tween 80
- Details on oral exposure:
- Groups of animals were observed for a period of one week and the signs of toxicity and total deaths in each group noted.
- Doses:
- Range-finding:
--------------
solid material: 5000 mg/kg, 2500 mg/kg, 1000 mg/kg and 500 mg/kg
liquid samples: 5.0 mL/kg, 2.5 mL/kg, 1.0 mL/kg and 0.5 mL/kg
LD 50 Determination:
-------------------
Mouse: 5 mL/kg - No. of animals per sex per dose:
- Range -finding:
--------------
Rats, Rabbits and Mice: Two animals per dose
LD 50 Mouse:
------------
Ten animals (5 male and 5 female mice) - Control animals:
- no
- Details on study design:
- All animals were fasted overnight prior to administration and provided their normal food and water subsequent to dosing. All materials were administered by gavage using metal cannulae for mice and rats and a rubber stomach catheter for rabbits.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- suspended in 10% aqueous solution
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No signs of toxicity or clinical signs observed.
- Gross pathology:
- No information available.
- Other findings:
- No other findings were detected.
Any other information on results incl. tables
Tylers Mice and New Zealand White Rabbits were also used in the LD50 investigation. No animals died during the observation period. No clinical signs were observed during the fourteen days.
Therefore, the LD50 of the test item for Mice is > 5 mL/kg bw at a dosing concentration of 10% aqueous solution and the LD50 for Rabbits is > 5 mL/kg bw (test item undiluted).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No animals died during the observation period. No clinical signs were observed during the fourteen days.
Therefore, the LD50 of the test item is > 5000 mg/kg bw. - Executive summary:
The study was conducted prior to GLP and OECD guideline implementation.
Acceptable for reliability but not in detail documented. Nevertheless, the study report meets basic scientific principles.
This study was undertaken to determine the oral median lethal dose (LD50) of test article LZ705 in Wistar rats. The study was performed during August 1973.
No animals died during the observation period. No clinical signs were observed during the fourteen days.
Therefore, the LD50 of the test item is > 5000 mg/kg bw.
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