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Diss Factsheets
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EC number: 223-032-9 | CAS number: 3699-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(2-hydroxyethyl)imidazolidin-2-one
- EC Number:
- 223-032-9
- EC Name:
- 1-(2-hydroxyethyl)imidazolidin-2-one
- Cas Number:
- 3699-54-5
- Molecular formula:
- C5H10N2O2
- IUPAC Name:
- 1-(2-hydroxyethyl)imidazolidin-2-one
- Details on test material:
- - Name of test material: HEEU
- Physical state: clear liquid containing 75% active ingredient
- Composition of test material, percentage of components: 1-(2-hydroxyethyl)imidazolidin-2-one: 75% Wt; water: 25% Wt.
- Lot/batch No.: Lot No. DLT 33:99
- Sample No.: 00-098
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD®BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Raleigh, NC
- Age at study initiation: males were approximately 8 weeks old and the females were approximately 9 weeks old
- Weight at study initiation: from 251 to 262 g for males and from 208 to 224 g for females
- Fasting period before study: overnight
- Housing: individually housed in suspended stainless steel cages (18x34x20 cm) with wire mesh fronts and bottoms
- Diet (ad libitum): PMI Certified Rodent Diet 5002(C) (Purina Mills Inc., Richmond, IN)
- Water (ad libitum): via automatic watering, purified by reverse osmosis
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 23°C. During the study, the average daily temperature ranged from 21 to 22°C
- Humidity (%): range of 30-70%. During the study, the average daily relative humidity ranged from 51 to 65%
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: between the flank and shoulders, shaved intact skin
- % coverage: 10% body surface area
- Type of wrap if used: polyethylene sheet covered with Elastoplast® (Beiersdorf, Inc., Norwalk, CT) and PEG®(Becton-Dickinson Co., Franklin Lakes, NJ) elastic bandages and secured in place with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with paper towels saturated with tap water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Concentration: 100% HEEU containing 75% active ingredient
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw (dose was calculated on an "as is" basis; no adjustment was made for percent active ingredient)
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Observations for signs of ill health or reaction to treatment at approximately 1, 2 and 4 hrs after dosing and once daily thereafter for 14 days.
Body weights were recorded on day 0 (prior to dosing) and on days 7 and 14.
- Necropsy of survivors performed: yes - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities were reported.
- Clinical signs:
- other: No clinical signs were reported.
- Gross pathology:
- Necropsy revealed no gross changes.
- Other findings:
- Periodically during the study, the fur surrounding the eyes and muzzle of several animals was observed to be red stained; these effects were judged to be caused by the occluded testing methodology and by the use of collars.
No skin irritation effects were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.