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EC number: 500-537-5 | CAS number: 161075-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 November 2013 to 31 January 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD Guideline-conform study conducted under GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Testing Guideline No.105 (1995)_Water Solubility
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC, Physico-chemical Methods for Technical and Formulated Pesticides
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.6 "water solubility" Council Regulation (EC) No 440/2008.
- Deviations:
- no
- Principles of method if other than guideline:
- No test guideline is currently available for the measurement of the solubility in n-Octanol, therefore the determination was based on the principles of OECD guideline No. 105 and EU Method A.6 “Water Solubility”.
- GLP compliance:
- yes (incl. QA statement)
- Medium:
- n-octanol
- Solubility:
- 12.7 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Method A Analysis: 5 minutes 5000 r.p.m. Centrifugation + GC/FID determination
- Medium:
- n-octanol
- Solubility:
- 24.2 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Method B Analysis: GC/FID determination
- Test substance stable:
- yes
- Details on results:
- The solubility in n-Octanol of the test item samples determined according to method A (including centrifugation) was 12.7 g/L at 20°C and 14.2 g/L at 20°C according to method B. The difference between the two values of solubility (defined with and without centrifugation) was ascribed to the presence of emulsions generated during the shaking phase which have been removed during the centrifugation step.
The higher variability in the analysis results of the three flasks analyzed without including the centrifugation phase is consistent with this hypothesis. - Conclusions:
- The n-Octanol solubility of the test item was determined to be 12.7 g/L.
- Executive summary:
The solubility in n-Octanol of the test item was determined under GLP according to OECD standard guidelines. Since no test guideline is currently available for the measurement of the solubility in n-Octanol the determination was based on the principles of OECD guideline No. 105 and EU Method A.6 “Water Solubility”.
A preliminary GLP test according to CIPAC method MT 157 was performed with the purpose of defining the range of solubility. The n-Octanol solubility of the test item resulted in the range 10 to 50 g/L therefore a definitive test according to shake flask method, including the analytical determination, was performed.
Three samples (about 2.5 g each) of test item were weighed into three 100 mL conical flasks, 100 mL of n-Octanol were added and each flask was closed with a polypropylene stopper in order to have the minimum head space.
Three flasks, labelled "A" "B" and "C" were shaken in a thermostatic oven with magnetic stirrer for 24 (Flask A), 48 (Flask B), and 72 (Flask C) hours, respectively. Then the flasks were allowed to stand at 20°C in a thermostatic oven for 24 hours. The solutions were collected and the concentration of test item was analytically determined by GC coupled with FID detector. Calculations were made by an external standard.
Since the test item is known for the tendency in forming emulsions when shaken, prior of the analytical determination every solution (A, B and C ) was treated according to two different methods, in order to verify the presence of emulsions:
Method A
An aliquot of each solution (A , B and C ) was centrifugated at 5000 r.p.m. for 5 minutes and then 5 mL of supernatant were transferred into 20.00 mL volumetric flask making to volume with n-Octanol. The resulting solutions were analyzed by GC/FID.
Method B
5 mL aliquots of each solution (A , B and C ) were transferred into 20.00 mL volumetric flask making to volume with n-Octanol. The resulting solutions were analyzed by GC/FID.
The solubility in n-Octanol of the test item samples determined according to method A (including centrifugation) was 12.7 g/L at 20°C while the solubility according to method B was 14.2 g/L at 20°C. The difference between the two values of solubility (defined with and without centrifugation) was ascribed to the presence of emulsions generated during the shaking phase which have been removed during the centrifugation step.
The higher variability in the analysis results of the three flasks analyzed without including the centrifugation phase is consistent with this hypothesis.
Basing on this the value of 12.7 g/L is considered more representative of the solubility of the test item in n-Octanol.
Reference
Table 1: n-Octanol solubility results _Method A : 5 minutes 5000 r.p.m. Centrifugation + GC/FID determination.
Flask / Replicate | Concentration (μg/mL) |
Mean (g/L) |
Flask A1 | 12656.1 | 12.67 |
Flask A2 | 12679.7 | |
Flask B1 | 12592.3 | 12.65 |
Flask B2 | 12706.8 | |
Flask C1 | 12798.5 | 12.80 |
Flask C2 | 12806.2 | |
Mean value | 12.7 | |
Standard Deviation | 0.08 | |
Relative Standard Deviation (%) | 0.66 % |
Table 2: n-Octanol solubility results _Method B: GC/FID determination
Flask / Replicate | Concentration (μg/mL) |
Mean (g/L) |
Flask A1 | 14084.2 | 14.07 |
Flask A2 | 14062.9 | |
Flask B1 | 13958.3 | 14.00 |
Flask B2 | 14044.9 | |
Flask C1 | 14642.0 | 14.66 |
Flask C2 | 14677.0 | |
Mean value | 14.2 | |
Standard Deviation | 0.36 | |
Relative Standard Deviation (%) | 2.53 % |
Description of key information
The solubility in n-Octanol of GALDEN LMW was experimetally determined to be 12.7 g/L.
Key value for chemical safety assessment
Additional information
The solubility in n-Octanol of the test item was determined under GLP according to OECD standard guidelines. Since no test guideline is currently available for the measurement of the solubility in n-Octanol the determination was based on the principles of OECD guideline No. 105 and EU Method A.6 “Water Solubility”.
According to the results, it can be concluded that the solubility of GALDEN LMW in n-Octanol is 12.7 g/L at 20°C.
Galden is a multi-constituent substance consisting of low molecular weight perfluoropolyethers (PFPE). Perfluorinated substances typically have a low affinity for water. Two grades of Galden LMW are manufactured (Galden HT55 and Galden HT70), which contain the same perfluorinated constituents and differ only in the relative concentration of the constituents.
As the two grades both contain only perfluorinated constituents (albeit in different relative concentrations), the solubility of both Galden grades is very similar. The value of 12.7 g/L therefore is representative for both grades.
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