Registration Dossier
Registration Dossier
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EC number: 927-033-1 | CAS number: 1174918-88-7
Endpoint summary
Administrative data
Description of key information
Irritating to the skin, based on a classified constituent. Not irritating to the eyes.
Key value for chemical safety assessment
Additional information
There are no skin or eye irritation data available on the hydrocarbons, C7-C8, cyclics. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.
The skin irritation potential of the hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was determined according to OECD 404 (Shell, 1987). The test substance was applied to the intact skin of rabbits for 4 hours under semiocclusive conditions. After removal of the test substance, no edema, but minimal erythema were noted in all animals (score 1). At 72 hours, all rabbits were still affected. All skin effects had cleared by 7 days.
In another study, the test substance was placed on intact skin of 4 rabbits, and covered with an occlusive patch (Shell, 1977). After 24 hours of exposure, animals were scored for dermal irritation (24, 48 and 72 h and 7 days after patch removal). Very slight erythema (score 1) were observed in all animals. At 7 days, 3 of 4 rabbits were still affected. Very slight edema were only observed at 24 hours after removal of the patches. Based on the experimental data, the test substance was not irritating to the skin.
The eye irritation potential of the hydrocarbons, C7-C9, n-alkanes, iso-alkanes, cyclics was determined by instillation of 0.2 mL of the test material into the conjunctival sac of 4 rabbits (Shell, 1977). A visual assessment of irritancy was made 30 min, 24, 48, 72 hours and 7 days after application. At 30 min after application, a very mild irritancy was observed in mild conjunctival redness (grade 0-1) in all animals. All redness was reversible within 24 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge was noted in any of the 4 rabbits.
Justification for classification or non-classification
Based on read-across from a structurally related substance within a category approach, the available data on the skin irritating potantial of hydrocarbons, C7-C8, cyclics are conclusive but not sufficient for classification. However, a constituent substance, methylcyclohexane (CAS No. 108-87-2), is classified as a skin irritant according to Annex VI to Regulation EC 1272/2008. Therefore, hydrocarbons, C7-C8, cyclics were considered as skin irritant and classified.
DSD: R38
CLP: Skin Irritation Category 2
Based on read-across from a structurally related substance within a category approach, the available data on the eye irritating potential of hydrocarbons, C7-C8, cyclics are conclusive but not sufficient for classification.
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