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EC number: 220-912-4 | CAS number: 2935-90-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted according to OECD Guideline 301 B "Ready Biodegradability: Modified Sturm Test (CO2 evolution)"
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl 3-mercaptopropionate
- EC Number:
- 220-912-4
- EC Name:
- Methyl 3-mercaptopropionate
- Cas Number:
- 2935-90-2
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- methyl 3-sulfanylpropanoate
- Details on test material:
- - Name of test material (as cited in study report): methyl 3-mercaptopropionate
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- Substance type: active
- Physical state: liquid
- Analytical purity: 99.75%
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
N/A
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: secondary effluent from a biologic treatment plant
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): : 2.6*E5 bacteria/mL medium
secondary effluent from a biologic treatment plant of Versailles, France.
- Laboratory culture: N/A
- Method of cultivation: N/A
- Storage conditions: N/A
- Storage length: N/A
- Preparation of inoculum for exposure: N/A
- Pretreatment: N/A
- Concentration of sludge: N/A
- Initial cell/biomass concentration: 2.6*E5 bacteria/mL
- Water filtered: N/A
- Type and size of filter used, if any: N/A - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 37.5 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: N/A
- Additional substrate: N/A
- Solubilising agent (type and concentration if used): N/A
- Test temperature: 22 deg. C
- pH: N/A
- pH adjusted: yes/no N/A
- CEC (meq/100 g): N/A
- Aeration of dilution water: N/A
- Suspended solids concentration: N/A
- Continuous darkness: yes/no: N/A
- Other: N/A
TEST SYSTEM
- Culturing apparatus: N/A
- Number of culture flasks/concentration: N/A
- Method used to create aerobic conditions: N/A
- Method used to create anaerobic conditions: N/A
- Measuring equipment: N/A
- Test performed in closed vessels due to significant volatility of test substance: N/A
- Test performed in open system: N/A
- Details of trap for CO2 and volatile organics if used: N/A
- Other: N/A
SAMPLING
- Sampling frequency: 0, 1, 5, 8, 14, 20, 27, 28 days
- Sampling method: N/A
- Sterility check if applicable: N/A
- Sample storage before analysis: N/A
- Other: N/A
CONTROL AND BLANK SYSTEM
- Inoculum blank: N/A
- Abiotic sterile control: N/A
- Toxicity control: N/A
- Other: Appropriate controls and blank system were used. Details were not available.
STATISTICAL METHODS: N/A
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Preliminary study:
- N/A
- Test performance:
- - 46% after 28 days
- 21% degradation in the 10 days window
- No inhibition of inoculum observed.
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 46
- Sampling time:
- 28 d
- Details on results:
- N/A
BOD5 / COD results
- Results with reference substance:
- Please see Tables 1-3 below.
Any other information on results incl. tables
Table 1. CO2 produced (mg/day)
Test Day |
0 |
1 |
5 |
8 |
14 |
20 |
27 |
28 |
Blank 1 |
0 |
2.1 |
3.1 |
2.5 |
3.2 |
3.2 |
2.9 |
0.8 |
Blank 2 |
0 |
2.3 |
9.5 |
2.4 |
3.0 |
1.9 |
2.2 |
0.4 |
Mean |
|
|
|
|
|
|
|
|
Blank |
0 |
2.2 |
6.3 |
2.5 |
3.1 |
2.1 |
2.5 |
0.6 |
Test 1 |
0 |
2.1 |
3.1 |
6.8 |
6.9 |
5.3 |
13.1 |
0.6 |
Test 2 |
0 |
1.8 |
4.4 |
0.6 |
6.4 |
5.4 |
18.4 |
0.9 |
Mean |
|
|
|
|
|
|
|
|
Test |
0 |
1.9 |
3.7 |
3.7 |
6.7 |
5.3 |
15.7 |
0.8 |
Ref substance |
0 |
33.2 |
35.3 |
2.6 |
2.2 |
1.0 |
0.2 |
0.2 |
Inhibition |
0 |
14.5 |
16.1 |
13.5 |
11.4 |
7.9 |
0.2 |
-0.1 |
Sterile |
0 |
2.2 |
1.3 |
0.4 |
0.1 |
-1.4 |
0.3 |
0.2 |
Reference substance is Sodium Benzoate.
Table 2. Cumulative CO2 produced (mg)
Test Day |
0 |
1 |
5 |
8 |
14 |
20 |
27 |
28 |
Blank 1 |
0 |
2.1 |
5.2 |
7.7 |
10.9 |
13.2 |
16.1 |
16.8 |
Blank 2 |
0 |
2.3 |
11.8 |
14.2 |
17.2 |
19.0 |
21.2 |
21.7 |
Mean |
|
|
|
|
|
|
|
|
Blank |
0 |
2.2 |
8.5 |
10.9 |
14.0 |
16.1 |
18.6 |
19.3 |
Test 1 |
0 |
2.1 |
5.2 |
11.9 |
18.9 |
24.1 |
37.2 |
37.8 |
Test 2 |
0 |
1.8 |
6.2 |
6.8 |
13.1 |
18.5 |
36.9 |
37.8 |
Mean |
|
|
|
|
|
|
|
|
Test |
0 |
1.9 |
5.7 |
9.3 |
16.0 |
23.1 |
37.1 |
37.8 |
Ref substance |
0 |
33.2 |
68.5 |
71.1 |
73.3 |
74.3 |
74.5 |
74.7 |
Inhibition |
0 |
14.5 |
30.6 |
44.1 |
55.5 |
63.4 |
63.6 |
63.6 |
Sterile |
0 |
2.2 |
3.5 |
4.0 |
4.1 |
2.6 |
3.0 |
3.2 |
Reference substance is Sodium Benzoate.
Table 3. Degradation (%)
Test Day |
0 |
1 |
5 |
8 |
14 |
20 |
27 |
28 |
Test 1 |
0 |
3 |
6 |
14 |
23 |
29 |
45 |
46 |
Test 2 |
0 |
2 |
7 |
8 |
16 |
22 |
45 |
46 |
Mean |
|
|
|
|
|
|
|
|
Test |
0 |
2 |
7 |
11 |
19 |
26 |
45 |
46 |
Ref substance |
0 |
40 |
83 |
86 |
89 |
90 |
90 |
91 |
Inhibition |
0 |
9 |
19 |
27 |
34 |
38 |
39 |
39 |
Sterile |
0 |
3 |
4 |
5 |
5 |
3 |
4 |
4 |
Reference substance is Sodium Benzoate.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- 46% degradation in 28 days; not readily biodegradable.
- Executive summary:
N/A
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