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EC number: 420-670-1 | CAS number: 37443-42-8 METHFAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 5 July 1990 to 12 July 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to internation guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl tetrahydro-2-furancarboxylate
- EC Number:
- 420-670-1
- EC Name:
- Methyl tetrahydro-2-furancarboxylate
- Cas Number:
- 37443-42-8
- Molecular formula:
- C6H10O3
- IUPAC Name:
- methyl oxolane-3-carboxylate
- Test material form:
- other: liquid
- Details on test material:
- Label identification: Methyl Tetrahydrofuroate (METHFAT)
Source: QO Chemicals, Inc. 2801 Kent Avenue P.0. Box 2500 West Lafeyette, Indiana 47906
Date received: February 23, 1990
Lot number: PP17-9J29
Purity: Assume 100% for acute testing
Physical description: Clear colorless liquid.
Storage conditions: Sealed container at room temperature.
Test material preparation: A sufficient amount of neat test material was transferred from its original container to a labeled vial that contained a stir bar and was maintained on a magnetic stir plate prior to dispensation and throughout the dosing procedure.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Number on study: Three males and three females
Body Weight Range: 2290 and 2511 grams at study initiation
Age at start of Study: Young adult
Method of identification: Ear tag
Housing: Individual suspended mesh-bottom cages. The animals were maintained by the animal husbandry staff of WIL Research Laboratories, Inc. in accordance with standard operating procedures.
Quarantine: The animals were acclimated to laboratory conditions for a minimum of 6 days prior to study initiation.
Food and water: Purina® Certified Rabbit Chow® #5322 and tap water from on-site wells. Analysis of feed is performed and provided by the manufacturer. Water is analyzed twice yearly in accordance with S.O.P. No. A-Q20.
Environmental conditions: Animal room with controlled temperature (67-70° F), humidity (56-76%) and light (12 hours light/12 hours dark). There were approximately ten fresh air changes per hour.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- The dose was 0.5 ml/site.
- Duration of treatment / exposure:
- 4 hour
- Observation period:
- 7 days
- Number of animals:
- One group of 6 rabbits.
- Details on study design:
- Test material preparation:
A sufficient amount of neat test material was transferred from its original container to a labeled vial that contained a stir bar and was maintained on a magnetic stir plate prior to dispensation and throughout the dosing procedure.
Method of test material administration:
On the day prior to dosing, the hair was removed from the backs of the rabbits using an Oster small animal clipper. Each 0.5 milliliter dose was applied under a secure 2- ply one inch square gauze patch that was overwrapped with a gauze binder that was secured with Dermiform®Tape. Plastic restraint collars were applied and remained on the animals for the duration of the exposure period.
Dose levels/group/treatment regimen:
The dose was 0.5 ml/site. There was one group of six rabbits, one intact site per rabbit. Each animal received a single, four-hour, semi-occluded exposure. At the end of four hours, the collars and bandages were removed and the sites wiped with wet disposable paper towels.
Mortality:
The rabbits were observed twice daily for mortality for the duration of the study.
Dermal Observations:
The application sites were observed for erythema, edema and other dermal findings at approximately 30-60 minutes and 24, 48 and 72 hours after patch removal and daily thereafter through day 7 if irritation persisted. Dermal irritation was graded in accordance with the method of Draize. In order to facilitate dermal observations the rabbits were shaved approximately 1-2 hours prior to collecting the 72 hour dermal scores.
Body Weights:
Body weights were obtained and recorded on study day 0 (initiation) and at the time of each rabbit's termination from study.
Termination:
Upon termination from the study, the rabbits were sacrificed by intravenous overdose of anesthesia and discarded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0 - 1
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The test material induced very slight erythema on three of the six rabbits. There was no edema. Desquamation was present on one site on days 4-6. All erythema completely subsided by day 4 or earlier. There were no other dermal findings.
The Primary Irritation Index was calculated to be 0.3. The test material METHFAT received a descriptive rating classification of slightly irritating. - Other effects:
- Mortality: None of the rabbits died.
Body weight: There were no significant body weight changes during the study period.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Primary Irritation Index was calculated to be 0.3. The test material, METHFAT, received a descriptive rating classification of slightly irritating.
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