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EC number: 209-090-8 | CAS number: 555-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- all information from the publication is included in the summary
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- standard OECD 202 test conditions
- GLP compliance:
- not specified
- Remarks:
- data published
- Specific details on test material used for the study:
- purity 99.99% (Wako)
- Analytical monitoring:
- yes
- Details on sampling:
- at 0 and 48 H
- Vehicle:
- no
- Details on test solutions:
- stock solution in distiiled water added directly to the test medium
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: National Institute for Environmental studies, Tsukuba, Japan
- Age of parental stock: maximum 2 weeks (fed chlorella vulgaris)
- Age of the daphnids in the test : <24 h
- Feeding during test: none
ACCLIMATION
- Acclimation period: no data - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- no data
- Test temperature:
- 21 ± °C
- pH:
- measured at 0 and 48 hours 6.5-8.5 (not adjusted)
- Dissolved oxygen:
- measured at 0 and 48 hours (not reported)
- Nominal and measured concentrations:
- no data, five concentrations with a dilution factor 2
- Details on test conditions:
- TEST SYSTEM: according to OECD 202
TEST MEDIUM / WATER PARAMETERS: tap water filtered with activated charcoal
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 16 h light/8 h dark
EFFECT PARAMETERS MEASURED: immobilisation
VEHICLE CONTROL PERFORMED: no vehicle used, medium control included
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 930 µg/L
- Conc. based on:
- test mat.
- Remarks:
- aluminium chloride
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- EC50 values calculated by Probit analysis
- Conclusions:
- Te EC50 of aluminium in daphnia magna was 3.9 mg/L (as Al)
- Executive summary:
In a test according to OECD 202, the EC50 of aluminium in daphnia magna was found to be 3.9 mg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- review of acute toxicity data
- GLP compliance:
- not specified
- Remarks:
- data published
- Specific details on test material used for the study:
- not further defined, expressed as mg Al/L
- Analytical monitoring:
- no
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 240 - <= 3 100 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Basis for effect:
- mortality
- Remarks on result:
- other: see table
- Conclusions:
- In a review article the LC50 of aluminium species to aquatic organisms was 97-10000 µg/L. The LC50 values for 72h were 240-3100 µg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Not GLP, no guideline followed, although it is similar to the most recent OECD 202 with some deviations, which did not affect results. It contains all the information necessary for the evaluation. Peer-reviewed article, it reports the LC50(24h) of 173 substances.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- 10 animals per conc. Test period 24 h. Oxygen concentration not measured. No controls.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Aluminium tri-isopropylate reacts instantaneously with water to form 2-propanol and Al3+ species. The resulting pH being weakly alkaline indicates according to Langmuir et al. 2004 that Al3+ species formed are mainly Al(OH)4-, Al(OH)3 and Al(OH)2+ at pH 8.5.
Thus, aluminium tri-isopropylate is abiotically degradable and forms 2-propanol being readily biodegradable as shown in the registration dossier of 2-propanol submitted by the same lead registrant. Thus, 2-propanol is the ideal surrogate for testing toxicity effects on daphnia posed by the organic moiety of the reference substance. - Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- hardness 16° dH (German)
- Test temperature:
- 20 - 22 °C
- pH:
- pH 7.6 – 7.7
- Dissolved oxygen:
- saturated
- Salinity:
- The test medium was tap water free from chlorine
- Details on test conditions:
- The test medium was tap water free from chlorine, saturated with oxygen, hardness 16° dH (German), pH 7.6 – 7.7, temperature 20 - 22°C.
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- LC0
- Effect conc.:
- 5 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50(24 h) of 2-propanol in the Daphnia sp. acute immobilisation test is: > 10000 mg/L
- Executive summary:
The 24 hour LC50 of 173 substances hazardous in water was determined by means of a standardized procedure using 24-h-old animals from a clone of Daphnia magna. At the same time, the LC0 (5000 mg/l for isopropanol) and LC100 (>10000 mg/l for isopropanol) for each of these pollutants were determined. The test medium was tap water free from chlorine, saturated with oxygen, hardness 16° dH (German), pH 7.6 – 7.7, temperature 20 - 22°C.
Referenceopen allclose all
Species Taxa |
Test type |
Duration (h) |
Endpoint |
Toxicity Measure |
Toxicity value* (µg/L) |
Ctenodrilus serratus Annelid |
Acute |
96 |
Mortality |
LC50 |
97 |
Balamus eburneus Crustacean |
Acute |
72 |
Mortality |
LC50 |
240 |
Capitella capitata Annelid |
Acute |
96 |
Mortality |
LC50 |
405 |
Cancer anthonyi Crustacean |
Chronic |
168 |
Mortality |
NOEC |
1000 |
Mytilus galloprovincialis Mollusc |
Acute |
72 |
Mortality |
LC50 |
2550 |
Artemia salina Crustacean |
Acute |
72 |
Mortality |
LC50 |
3100 |
Nitocra spinipesCrustacean |
Acute |
96 |
Mortality |
LC50 |
10000 |
*Nominal total aluminium concentrations
Description of key information
Aluminium tri-isopropanolate dissociates instantaneously when exposed to water forming isopropanol and aluminium(III) species. Therefore the effects of both hydrolysis products are considered most relevant to assess the toxicity of aluminium tri-isopropanolate.
In a test according to OECD 202, the EC50 of aluminium chloride in daphnia magna was found to be 3.9 mg Al/L (Okamoto 2015). In a review of acute toxicity tests on several marine species the LC50 varied betweeen 97 and 10000 ug/L (Golding 2015)
For isopropanol the 24 hour EC50 was determined by means of a standardized procedure using 24-h-old animals from a clone of Daphnia magna at > 10000 mg/L (Bringmann 1977).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.9 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 97 µg/L
Additional information
Aluminium tri-isopropanolate reacts instantaneously with water to form isopropanol and Al3+ species. The resulting pH being weakly alkaline indicates according to Langmuir et al. 2004 that Al3+ species formed are mainly Al(OH)4-, Al(OH)3 and Al(OH)2+ at pH 8.5.
Aluminium tri-isopropanolate is abiotically degradable and forms isopropanol being rapidly biodegradable as shown in a publication by Bridie (1979).
Hence, both isopropanol and aluminium species will be present in aqueous media. Based on its toxicity, aluminium species seem to represent a worst case surrogate for assessing toxicity to aquatic species exposed to the substance, aluminium tri-isopropanolate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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