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Diss Factsheets
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EC number: 206-190-3 | CAS number: 306-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable method not GLP, no OECD TG followed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro- -
- IUPAC Name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro- -
- Details on test material:
- - Name of test material (as cited in study report): Ethane, 1,1-dichloro-2,2,2-trifluoro (FC-123)
- Other: OCNB-173-17
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- other: propylene glycol
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- Group 1: 0.1 mL undiluted test substance
Group 2: 0.2 mL 50:50 mixture of test substance and propylene glycol
Group 3: 0.1 mL propylene glycol - Duration of treatment / exposure:
- 20 seconds (washed eye) to 14 days (unwashed eye)
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- - Two animals per group.
- Details on study design:
- The appropriate dose of material was placed in the right conjunctival sac of each of two albino rabbits. In all groups, after 20 seconds, one treated eye was washed with tap water for one minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris, and conjunctiva were made with a hand-slit lamp at one and four hours, and at one, two, three, seven, and fourteen days. Fluorescein stain and a biomicroscope were used at examinations after the day of treatment.
The test chemical, the 50:50 mixture, and propylene glycol were chilled in a refrigerator and administered with a cold glass syringe.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: See attached Table
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: See attached Table
- Irritant / corrosive response data:
- See attached Table 1.
Undiluted Ethane, 1,1-dichloro-2,2,2-trifluoro produced mild to moderate conjuctival irritation with no corneal or iritic involvement in an unwashed rabbit eye. An eye dosed with the test substance and promptly washed had mild to slight transient corneal opacity and mild to moderate conjunctival irritation with no iritic involvement. Both eyes were normal within 3-7 days.
Any other information on results incl. tables
Eyes dosed with the 50:50 mixture had slight to moderate corneal opacity with partial circumcorneal vascularization, mild iritic congestion, and mild to severe conjunctival irritation. The washed eye had slight to moderate corneal opacity, slight iritic congestion, and mild to moderate conjunctival irritation. Both eyes were normal within 14 days.
Eyes dosed with propylene glycol produced mild to moderate conjunctival irritation. Both eyes were normal within 3 days.
The eyes dosed with the 50:50 mixture were much more irritated than those dosed with the neat material. The reason was probably because the mixture allowed HCFC-123 to be in intimate contact with the eye longer than the neat HCFC-123 which boiled out.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, ethane, 1,1-dichloro-2,2,2-trifluoro produced mild to moderate conjuctival irritation with no corneal or iritic involvement in an unwashed rabbit eye. An eye dosed with the test substance and promptly washed had mild to slight transient corneal opacity and mild to moderate conjunctival irritation with no iritic involvment. Both eyes were normal within 3-7 days.
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