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EC number: 246-896-9 | CAS number: 25360-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-03-31
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restrictions because it was an acceptable, well-documented study report which met basic scientific standards.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- No guideline available. Outbred young adult SPF male mice (Charles River Laboratories) were exposed, head only, to the LC50 concentration of Sulfole 90 for one minute, followed by room air for ten minutes, and Sulfole 90 for one minute. The respiratory patterns of the mice were continuously monitored during exposure and for at least five minutes following exposure termination. The basic method was developed by Y. Alarie (Arch. Environ. Health, 13:433-449, 1966).
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- 1,1-dimethylheptanethiol (CAS # 25360-10-5)
- IUPAC Name:
- 1,1-dimethylheptanethiol (CAS # 25360-10-5)
- Details on test material:
- Name of test material (as cited in study report): Sulfole 90
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- - Amount(s) applied (volume or weight with unit): 1067.5 ppm S.D. 3.54 (7.00 mg/L S.D. 0.02)
- Nominal Concentration: 2.54 mg/L - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure was 1 minute, followed by 10 minutes in room air, followed by another 1 minute exposure.
- Post exposure period:
- The animals were observed during the exposures and for at least five minutes or until recovery from exposure.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
7.0 mg/L (1067 ppm or 7000 mg/m3)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
2.54 mg/L
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- TEST SITE
- Area of exposure: head only
SCORING SYSTEM: plethysomographic respiratory response
Results and discussion
- Details on results:
- One mouse experienced a 0-25% decrease in respiratory rate during the first exposure. Two mice experienced the 0-25% decrease in respiratory rate during the second exposure to 7.0 mg/L.
Applicant's summary and conclusion
- Conclusions:
- In a respiratory irritation tract study, four male outbred SPF mice were exposed via head-only inhalation to 7.00 mg/L (1067.5 ppm) of 1,1-dimethylheptanethiol for two periods of 1 minute exposures separated by a 10 minute exposure to room air. Based on the results the authors concluded that the test material is not an irritant when 7.00 mg/L is inhaled by mice.
- Executive summary:
In a respiratory irritation tract study, four male outbred SPF mice were exposed via head-only inhalation to 7.00 mg/L (1067.5 ppm) of 1,1-dimethylheptanethiol for two periods of 1 minute exposures separated by a 10 minute exposure to room air. Animals were then observed for 5 minutes or until the respiratory rate returned to pre-exposure rates.
The test material was applied as a vapour in a head only exposure chamber attached to a plethymograph. One of the four mice demonstrated changes in respiratory rates during the first minute (0 -25% decrease in respiratory rate) and two mice in the second minute (0 -25% decrease in respiratory rate) of exposure to 7.00 mg/L1,1-dimethylheptanethiol. Based on the results the authors concluded that the test material is not an irritant when 7.00 mg/L is inhaled by mice. Compound-induced corrosion was not reported.
This study received a Klimisch score of 2 and was classified as reliable with restrictions because it was an acceptable, well-documented study report which met basic scientific standards.
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