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EC number: 231-842-9 | CAS number: 7758-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- publication
- Title:
- Copper Monochloride CAS No: 7758-89-6, Final 10/2006
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- INCHEM 2009
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Copper chloride
- EC Number:
- 231-842-9
- EC Name:
- Copper chloride
- Cas Number:
- 7758-89-6
- Molecular formula:
- Cl Cu
- IUPAC Name:
- λ¹-copper(1+) chloride
- Details on test material:
- - Name of test material (as cited in study report): Copper monochloride (CuCl)
- Analytical purity: 97%
- Lot/batch No.: Sigma-Aldrich corporation, Lot No. 17119BO
Constituent 1
Method
- Target gene:
- his, trp
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium (strains TA 98, TA 100, TA 1535, TA 1537 and Escherichia coli (strain WP2 uvrA)
- Metabolic activation:
- with and without
- Metabolic activation system:
- - Species and cell type: Rat (Sprague Dawley strain), male, liver - Quantity: 5 % S9 mix induced with Aroclor 1254
- Test concentrations with justification for top dose:
- 3.7, 11.1, 33.3, 100, 300, 1000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: sterile distilled water
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- sterile distilled water
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: 2-Nitrofluorene, Sodium azide, 9-Aminoacridine, 4-Nitroquinoline and 2-Aminoanthracene
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in medium; in agar (plate incorporation); preincubation; in suspension; as impregnation on paper disk
- no data
DURATION
- no data
NUMBER OF REPLICATIONS:
- Number of replicated: one
- Frequency of Dosing: 3 plates/dose
NUMBER OF CELLS EVALUATED:
- no data
DETERMINATION OF CYTOTOXICITY
- Method: mitotic index; cloning efficiency; relative total growth; other:
OTHER:
Description of follow up repeat study: Dose range finding experiment was carried out using dose levels with 5-fold intervals of 1.6, 8, 40, 200, 1000
and 5000 μg/plate both in the absence and in the presence of metabolic activation system. - Evaluation criteria:
- Criteria for evaluating results: The number of revertant colonies increased significantly in at least one strain at one or more concentrations or the data
set showing a dose related correlation. - Statistics:
- Dunnett’s test
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 and Escherichia coli WP2uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: With metabolic activation: at above 300 µg/plate (TA 98, TA 100 and TA 1537, E. coli WP2 uvrA); Without metabolic activation: at 1,000 g/plate (TA 98, TA 100 and TA 1537)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- High statistical significance was only observed in positive control groups.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- CL-Freetext:
No mutation in the Salmonella typhimurium (strains TA 98, TA 100, TA 1535 and TA 1537) and Escherichia coli (strain WP2 uvrA) occurred with copper monochloride.
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