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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
from to 16-6-1992 until 30-06-1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-dichloroaniline
EC Number:
210-157-9
EC Name:
2,3-dichloroaniline
Cas Number:
608-27-5
Molecular formula:
C6H5Cl2N
IUPAC Name:
2,3-dichloroaniline
Details on test material:
- Name of test material (as cited in study report): 2,3-dichloroaniline pure
- Physical state: liquid
- Analytical purity: 99.5%
- Lot/batch No.: 1
- Stability under test conditions: guaranteed for the study period
- Storage condition of test material: refrigerator

Test animals

Species:
rabbit
Strain:
other: HC:NZW

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
other: none
Controls:
other: Skin area not treated with test substance served as control
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
4 hour(s)
Observation period:
24, 48, and 72 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24, 48, and 72 hours
Score:
3
Max. score:
4
Reversibility:
not fully reversible within: 7 and 14 days
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24, 48, and 72 hours
Score:
3
Max. score:
4
Reversibility:
not fully reversible within: 7 and 14 days
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24, 48, and 72 hours
Score:
2.7
Max. score:
4
Reversibility:
not fully reversible within: 7 and 14 days
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24, 48, and 72 hours
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24, 48, and 72 hours
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24, 48, and 72 hours
Score:
1.7
Max. score:
4
Reversibility:
not fully reversible within: within 7 days
Other effects:
Eschar formation occurred in all rabbits on exposed skin up to 14 days post exposure; skin was fissured in all 3 rabbits on day 1, 2, and 7 which proved to be reversible within 14 days; skin was hardened on day 7 in 1/3 rabbits -whitish squamous coat on the skin in all 3 rabbits on day 14

Applicant's summary and conclusion

Executive summary:

Bayer, 1992:


Eschar formation occurred in all rabbits on exposed skin up to 14 days post exposure; skin was fissured in all 3 rabbits on day 1, 2, and 7 which proved to be reversible within 14 days; skin was hardened on day 7 in 1/3 rabbits -whitish squamous coat on the skin in all 3 rabbits on day 14.