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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association This data valid as documented CCRF for this category (Acetylenic geminalic diols)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association
Deviations:
no
Principles of method if other than guideline:
Method: other
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,7,9-tetramethyldec-5-yne-4,7-diol
EC Number:
204-809-1
EC Name:
2,4,7,9-tetramethyldec-5-yne-4,7-diol
Cas Number:
126-86-3
Molecular formula:
C14H26O2
IUPAC Name:
2,4,7,9-tetramethyldec-5-yne-4,7-diol
Details on test material:
Sample# bl 1636

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Remarks:
other
Doses:
500 mg per kg of body weight
No. of animals per sex per dose:
5 male and 5 female
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 500 mg/kg bw
Mortality:
no mortality
Gross pathology:
Necropsy of all animals following sacrifice revealed at the end of the 14-day post-dose observation period, no gross pathological changes that could be attributed to administration were observed.

Any other information on results incl. tables

RS-Freetext:
All animals survived, showed no abnormal clinical signs and
gained weight.  Gross necropsy did not reveal any test
material-related pathological changes.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The oral administration to rats of 500 mg of Surfynol 104 per kg of body weight resulted in no mortality.
Accordingly, the submitted test material is not considered a toxic material orally, under the definition set forth by the
Manufacturing Chemist´s Association.
Executive summary:

The oral administration to rats of 500 mg of Surfynol 104 per kg of body weight resulted in no mortality.

Accordingly, the submitted test material is not considered a toxic material orally, under the definition set forth by the

Manufacturing Chemist´s Association.