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EC number: 280-445-7 | CAS number: 83411-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 29th to November 11th, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- GLP guideline study with some restrictions: no certificate of analysis and no data on the animal environmental conditions, occlusive dressing, abrasion of skin prior to application of test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- : no certificate of analysis and no data on the animal environmental conditions (temperature, humidity, air change), occlusive dressing, abrasion of skin prior to application of test substance.
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(2,4,4-trimethylpentyl)phosphinic acid
- EC Number:
- 280-445-7
- EC Name:
- Bis(2,4,4-trimethylpentyl)phosphinic acid
- Cas Number:
- 83411-71-6
- Molecular formula:
- C16H35O2P
- IUPAC Name:
- bis(2,4,4-trimethylpentyl)phosphinic acid
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Willow Pond Rabbitry, Montpelier, Indiana, USA
- Age at study initiation: no data
- Weight at study initiation: from 2.20 to 2.48 kg
- Fasting period before study: no
- Housing: individually housed in wire-bottomed cages suspended above the droppings.
- Diet (e.g. ad libitum): Purina Certified Rabbit Chow 5322, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: yes for 10 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back of rabbit
- % coverage: 10 % of the total body surface (approximately 240 cm²)
- Type of wrap if used: layer of 4-ply gauze and two single layers tock. The trunk of the rabbit was then wrapped with rubber latex dental dam and the dental dam taped at the edges with 1 inch micropore tape to form an airtight occlusive wrap.
- The skin of rabbits was abraded prior to treatment by making a series of parallel, epidermal abrasions, every 2 or 3 centimeters longitudinally with a 25 -gauze hypodermic needle. These abrasions were made sufficiently deep to penetrate the stratum cornuem but not to disturb the derma or to produce bleeding.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the residual test material was wiped off
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.94 ml/kg
- Concentration (if solution): not applicable, the substance is applied as supplied (pure substance)
- Constant volume or concentration used: not applicable, only one dose level was tested
- For solids, paste formed: not applicable - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations of the animals at least twice daily, weighing at day -1; 0; 2; 3; 6; 10 and 13
- Necropsy of survivors performed: yes: on the visceral and thoracic cavities
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- if mortality occured, the LD50 would be calculated according to the Lichtfield and Wilcoxon method.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no death occured
- Clinical signs:
- other: no animals exhibited signs of systemic toxicity. The evaluation of local skin reactions revealed mild to slight erythema in all animals over total surface area to scattered patches, day 1 through 13, and mild to slight edema in 9/10 animals over total sur
- Gross pathology:
- The examination of the visceral and thoracic cavities of the test animals revealed a congestion of illeum in one male. There were no significant gross pathologic findings in all other animals.
- Other findings:
- no other findings
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified as harmful or toxic according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- LD50 (rabbit, male/female)> 2000 mg/kg bw
- Executive summary:
In a limit acute dermal toxicity study performed similarly to the OECD test guideline No. 402 and in compliance with GLP, young adult albino New Zealand rabbits (5/sex) were dermally exposed to undiluted test material at the dose level of 2000 mg/kg bw. Prior to treatment, the skin of all animals was abraded (worst case approach). The treated area of dorsum (10 %) was covered by an occlusive dressing for 24 hours. Twenty-four hours after the start of exposure, the dressing was removed, the remained test material was wiped off and the animals were then observed for 14 days.
No animal died during the study and no animals exhibited signs of systemic toxicity. However, the evaluation of local skin reactions revealed mild to slight erythema in all animals over total surface area to scattered patches, day 1 through 13, and mild to slight edema in 9/10 animals over total surface to 1/4 surface area days 1 through 13. Furthermore, slight to moderate atonia, moderate to slight cracking, slight scaling, exfoliation, and dark and blue areas were observed on skin animals after the removal of the dressing and through several days following this removal. Those skin effects are in favour of a skin irritant potential of the substance. However the experimental conditions (abraded skin, exposure for 24hrs under occlusive patch) are too drastic to determine the skin irritation classification according to the current criteria for classification available in the Regulation (EC) 1272/2008 (CLP).ù
LD50 (rabbit, male/female)> 2000 mg/kg bw
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