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EC number: 201-137-0 | CAS number: 78-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxicity observed even at highest concentration level tested.
RA_CAS 67-48-1_Scenedesmus subspicatus_DIN 38412 L9: ErC10(72h) > 500 mg/L, EbC10(72h) > 500 mg/L, ErC50(72h) > 500 mg/L, EbC50(72h) > 500 mg/L, ErC10(96h) > 500 mg/L, EbC10(96h) > 500 mg/L, ErC50(96h) > 500 mg/L, EbC50(96h) > 500 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 500 mg/L
- EC10 or NOEC for freshwater algae:
- 500 mg/L
Additional information
Toxicity to aquatic algae was not investigated with the target substance Choline hydrogen carbonate. A valid experimental result is available for the reliable read-across substance Choline chloride (CAS 67-48-1). Both substances belong to the group of quaternary amine salts (more specific: choline salts, i.e. (2-hydroxyethyl)trimethylammonium salts), which will dissociate immediately in aqueous environment. Choline and its metabolites are important for different functions in the body of animate beings and thus a naturally occurring compound. Thus, the substance characteristics of both substances are comparable. For the detailed justification of this procedure, please refer to the separate read-across statement by Chemservice S.A. (2013).
Scenedesmus subspicatus (new name: Desmodesmus subspicatus) was used in an experiment according to the German guideline DIN 38412 L9 in order to test the toxicity of Choline chloride towards freshwater algae (BASF AG, 1989). Test concentrations were chosen as followed: 0 (control), 10, 25, 50, 100, 250 and 500 mg/L.
Potassium dichromate served as reference substance. Samples were taken and evaluated after 72 and 96h. A fluorometric determination of the cell count was performed every 24 h. As results, the EC50(72h) and EC50(96h) resulted in values > 500 mg/L based on growth rate as well as on biomass, respectively. The same applies to the determined EC10 values after 72 h and 96 h.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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