Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-380-4 | CAS number: 13768-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6th-14th May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Perrhenic acid
- EC Number:
- 237-380-4
- EC Name:
- Perrhenic acid
- Cas Number:
- 13768-11-1
- Molecular formula:
- H.O4Re
- IUPAC Name:
- rheniumoylol
- Reference substance name:
- Perrhenic acid solution
- IUPAC Name:
- Perrhenic acid solution
- Test material form:
- other: Solution
- Details on test material:
- - Name of test material (as cited in study report): Perrhenic acid, solution.
- Physical state: Liquid.
- Analytical purity: Not specified.
- Impurities (identity and concentrations): Not specified.
- Composition of test material, percentage of components: 54.6% Hydroxotrioxorhenium.
- Isomers composition: Not specified.
- Purity test date: Not specified.
- Lot/batch No.: 10510.
- Expiration date of the lot/batch: 31 December 2013.
- Stability under test conditions: Not specified.
- Storage condition of test material: Room temperature.
Constituent 1
Constituent 2
Test animals
- Species:
- other: Not applicable.
- Strain:
- other: Not applicable.
- Details on test animals or test system and environmental conditions:
- the CORROSITEX Assay is a standardized, quantitative in vitro test for skin corrosivity and has been validated by the ECVAM for testing acids, bases and their derivatives.
The test was performed on a synthetic macromolecular bio-barrier membrane resting on top of a chemical detection system (CDS). The BIOBARRIER was prepared 2 hours prior to tests. BIOBARRIER diluent and matrix powder were combined and heated to 68 deg C under smooth agitation. After complete dissolution, the solution was allowed to sit for 5 minutes. 200 ul of the BIOBARRIER were pipetted into each membrane disc, set on the tray and kept in the cold (2-8 deg C) for at least 2 hours.
Test system
- Type of coverage:
- other: Not applicable.
- Preparation of test site:
- other: Not apllicable.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Negative control: Citric acid (10%) in aqua dest. Positive control: Nitric acid (69%) and Phosphoric acid (85%).
- Amount / concentration applied:
- 500 ul
- Duration of treatment / exposure:
- Not applicable.
- Observation period:
- The test system was observed until a reaction was detected or for a total of 240 minutes.
- Number of animals:
- Not applicable.
- Details on study design:
- Test system:
The CORROSITEX™ test system was purchased from Invitro International, Irvine, CA 92614.
Qualification test:
This stage was carried out to ensure the sample is compatable with the CORROSITEX™ test system. 150 ul of the test substance was added to the Qualify test tube, shaken and left to stand for one minute. A colour change or change in consistency of the CDS indicates that the test material is qualified for the assay.
Categorization test:
To establish the category cut-off times for the sample, 150 ul of the test substance was added to tubes labeled A and B. After shaking, a colour change observed in either tube was matched to the corresponding CORROSITEX™ colour charts. Test material with high acid/alkaline reserves are defined as category 1, and those with low acid/alkaline reserves as category 2. If no colour is observed, a CONFIRM reagaent is used followed by pH testing.
Classification test:
The test was performed in vials that came pre-filled with the CDS. Four replicate vials were performed on the test substance. The CDS vials were warmed to room temperature (17-25 deg C) before use. A BIOBARRIER membrane disc was placed on top of a vial filled with CDS. 500 uL of the test item was placed on top of the BIOBARRIER membrane disc and starting time recorded. This was repeated with the remaining test vials, staggering each start time. The vials were observed for a reaction. The exact time of reactions were recorded.
Testing of positive and negative control substances:
Positive (nitric acid and phosphoric acid) and negative (citric acid) control substances were tested following the same procedure as the test substance assay. The expected reaction time ranges of the positive and negative control substances are within 3 minutes, 3 - 60 minutes and >60 minutes, respectively.
Data compilation:
The CORROSITEX™ time was calculated for each replicate by subtracting the start time from the detection time. The mean CORROSITEX™ time was calculated for the four test vials. Using the corrosivity assignment time table the appropriate Packing Group Classification was assigned.
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: CORROSITEX™ time
- Remarks on result:
- other:
- Remarks:
- Basis: mean time over 4 replicates. Time point: 2.21. Remarks: Corrosive. (migrated information)
Any other information on results incl. tables
Qualification/categorization test:
The test substance was compatible with the CORROSITEX™ test system based on the color change observed. In the categorization test a direct colour change was obseved in tube A and the category was read from the CORROSITEX™ colour chart. The test substance was assigned to Category 1.
Positive and negative control test substances:
The reaction time of positive controls nitric acid and phosphoric acid were 1.40 minutes and 16 minutes, respectively. The reaction time of the negative control was 83 minutes.
CORROSITEX™ Assay:
The mean time of the test substance to activate the CDS was 2.21 minutes.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: other: US GHS
- Conclusions:
- In a well conducted in vitro membrane barrier test (CORROSITEX™ Assay), the test substance is classified as "corrosive" sub category 1A, according to US GHS, as the mean time to activate the CDS was between 0-3 minutes (category 1). The test substance is therefore assigned to Packing group 1 and to EU risk phrase R 35.
- Executive summary:
In a good quality GLP study, conducted according to OECD guideline 435, the potential of the test substance to induce skin corrosion was assessed by performing the "in vitro membrane barrier test (CORROSITEX™ Assay)".
The test item was placed on top of a BIOBARRIER membrane which was on top of a vial filled with a chemical detection system (CDS). Corrosivity is determined on the ability (measured by the time taken) of a chemical to break through the barrier and subsequently activate the underlying CDS (as seen by a colour or consistency change). The mean time required for perrhenic acid solution to activate the CDS was 2.21 minutes (mean of 4 replicates).
The test substance is therefore classified as "corrosive" sub category 1A, according to US GHS, as the mean time to activate the CDS was between 0-3 minutes (category 1), and assigned to Packing group 1 and to EU risk phrase R 35.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.