Registration Dossier
Registration Dossier
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EC number: 250-439-9 | CAS number: 31027-31-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: cited in BG 249 (Hoechst study)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- p-isopropylphenyl isocyanate
- EC Number:
- 250-439-9
- EC Name:
- p-isopropylphenyl isocyanate
- Cas Number:
- 31027-31-3
- Molecular formula:
- C10H11NO
- IUPAC Name:
- 1-isocyanato-4-(propan-2-yl)benzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- up to 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Mortality:
- dosage of 3150 to 4000 mg/kg bw no death occured. with 5000 mg/kg bw 2 males and 3 females died. the male animals died within the first day, the female animals died between day 9 and day 14.
- Clinical signs:
- other: ruffled coat, diminished activity, increased startle response, constricted eye lids, diarrhoe, gasping at the highest dose
- Gross pathology:
- intestine filled with white-yellowish pulp, accumulation of blood in the lung, thorax filled with red liquid, liver partly brighten
Any other information on results incl. tables
Male animals died within the first day post application, the female animals died between day 9 and day 14. In these animals the intestine with white-yellow pulp, lungs were hemorrhagicand thorax filled with red liquid. Until the second day post application clinical signs were seen in all dose groups, specially crouch, elevated startle response, ruff fur, constricted eye palpebral fissure and diarrhoea. Three days after application of the test substance no clinical signs were evident. Animals killed after post observation period (14 to 21 days) were free of maroscopic visible changes
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
method: oral toxicty study according OECD 401.
result: LD50 is about 5000 mg/kg bw
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