Registration Dossier
Registration Dossier
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EC number: 221-259-8 | CAS number: 3048-64-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 hr LC50 in Zebra fish ((Brachydanio rerio): 7.6 mg/L.
96 hr LC50 in Medaka ((Oryzia latipes): 7 mg/L.
QSAR estimate 3.12mg/l.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.6 mg/L
Additional information
In a reliable reliable acute toxicity study of the read across substance ENB in fish, the 96-hr LC50for Zebra fish (Brachydanio rerio) was 7.6 mg/L and the 96-hr NOEC was 5.02 mg/L. US EPA ECOSAR software (v1.00a) estimates the 96 -hr fish LC50 for VNB substance to be 3.46mg/l and the surrogate read across substance ENB to 3.12 mg/L, based on structure activity relationship models for neutral organic compounds. Since the QSAR predicts the toxicity of ENB and VNB to be similar with the former the marginally more toxic, it seems both reasonable and conservative to select the key parameter from the measured data using the read across substance ENB.
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