Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 611-631-1 | CAS number: 58190-57-1
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Key study: Based on the read-across approach from experimental results on analogue substance VAC3 (EU method C.7., GLP study), the half-life of EAC3 was determined to be less than 1 hour at pH 4, 7 and 9 and at 25 ºC.
Key study: Based on the read-across approach from experimental results on analogue substance MAC3 (EU method C.7., GLP study), the half-life of EAC3 was determined to be less than 1 hour at pH 4, 7 and 9 and at 25 ºC.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 h
- at the temperature of:
- 25 °C
Additional information
Key study: Read-across from experimental results on analogue VAC3:
The hydrolysis as a function of pH study was performed according to EU method C.7. and GLP (reliability 1) with the analogue substance VAC3 (component of reaction mass Wasxo-VMAC2). The rate constant of hydrolysis and half-life were determined at pH 4, 7 and 9 at 25 ºC. The analysed concentration by gas chromatography was below the limit of quantification (0.94 mg/mL) at 0.75 h after starting the dissolution of the test substance. More than 50% of VAC3 hydrolysed at pH 4, 7 and 9 in less than 1 hour at 25 ºC. Based on these results, the read-across was applied and the half-life of EAC3 was determined to be less than 1 hour at pH 4, 7 and 9 and at 25 ºC.
Key study: Read-across from experimental results on analogue MAC3:
The hydrolysis as a function of pH study was performed according to EU method C.7. and GLP (reliability 1) with the analogue substance MAC3 (component of reaction mass Wasxo-VMAC2). The rate constant of hydrolysis and half-life were determined at pH 4, 7 and 9 at 25 ºC. The analysed concentration by gas chromatography was below the limit of quantification (0.94 mg/mL) at 0.75 h after starting the dissolution of the test substance. More than 50% of VAC3 hydrolysed at pH 4, 7 and 9 in less than 1 hour at 25 ºC. Based on these results, the read-across was applied and the half-life of EAC3 was determined to be less than 1 hour at pH 4, 7 and 9 and at 25 ºC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
