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EC number: 627-085-2 | CAS number: 1238449-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-08-16 to 2011-09-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study OECD and EU guidelines were followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Version / remarks:
- July 22, 2010
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- April 24, 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Experimental Toxicology and Ecology BASF SE
Test material
- Reference substance name:
- bis(2-propylheptyl) carbonate
- EC Number:
- 627-085-2
- Cas Number:
- 1238449-42-7
- Molecular formula:
- C21H42O3
- IUPAC Name:
- bis(2-propylheptyl) carbonate
- Reference substance name:
- Carbonic acid, bis (2-propylheptyl)ester
- IUPAC Name:
- Carbonic acid, bis (2-propylheptyl)ester
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- human
- Strain:
- other: human epidermis model
- Details on test animals or test system and environmental conditions:
- Test system:
- Model: three dimensionl human epidermis model:
The EpiDermTM model consists of normal, human-derived epidermal keratinocytes which have been cultured to form a multi layered, highly differentiated model of the human epidermis. It consists of organized basal, spinous and granular layers, and a multi-layered stratum corneum containing intercellular lamellar lipid layers arranged in patterns analogous to those found in vivo. The EpiDermTM tissues (surface 0.6 cm²) are cultured on specially prepared cell culture inserts (MILLICELLs®, 10 mm ∅) and commercially available as kits (EpiDerm™ 200), containing 24 tissues on shipping agarose.
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: negative control (historical control data)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 30 µL of the test substance - Duration of treatment / exposure:
- 1 hour
- Observation period:
- 42 hours
- Number of animals:
- NA
- Details on study design:
- TEST SITE
- Area of exposure: 0.6 cm2
SCORING SYSTEM:
Table(s) and/or figure(s) of measured parameters presented in the report were produced using PC based tabular calculation software. The mean and individual data were not always rounded but the significant digits were produced by changing the display format. As a consequence, calculation of mean values using the individual data presented in the report will, in some instances, yield minor variations in value.
- Principle: The OD570 values determined for the various tissues are measures of their viability. The quotient of the OD570 of tissues treated with the test material and the mean OD570 values of the NC (percent of control) is used for evaluating whether or not a test material is irritant.
- Calculation of individual and mean optical densities: The individual tissue OD570 is calculated by subtracting the mean blank value of the respective microtiter plate from the respective individual tissue OD570 value. The mean OD570 for a test group of three tissues treated in the same way is calculated.
- Tissue viability: The quantification of tissue viability is presented as the quotient of the mean OD570 divided by the respective OD570 NC value in percent.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: mean OD570
- Basis:
- other: tissue 1
- Time point:
- other: 42 h
- Score:
- 1.974
- Irritation parameter:
- other: mean OD570
- Basis:
- other: tissue 2
- Time point:
- other: 42 h
- Score:
- 1.989
- Irritation parameter:
- other: mean OD 570
- Basis:
- other: tissue 3
- Time point:
- other: 42 h
- Score:
- 2.012
- Irritation parameter:
- other: mean OD570
- Basis:
- mean
- Time point:
- other: 42 h
- Score:
- 1.992
- Irritation parameter:
- other: viability (% of negative control)
- Basis:
- other: tissue 1
- Time point:
- other: 42 h
- Score:
- 99.6
- Irritation parameter:
- other: viability (% of negative control)
- Basis:
- other: tissue 2
- Time point:
- other: 42 h
- Score:
- 100.4
- Irritation parameter:
- other: viability (% of negative control)
- Basis:
- other: tissue 3
- Time point:
- other: 42 h
- Score:
- 101.5
- Irritation parameter:
- other: viability (% of negative control)
- Basis:
- mean
- Time point:
- other: 42 h
- Score:
- 101
- Irritant / corrosive response data:
- The test substance is not able to reduce tetrazolium salt (MTT) directly. The mean viability of the test-substance treated tissues determined after an exposure period of 1 hour with about 42 hours post-incubation was about 101%.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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