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Diss Factsheets
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EC number: 212-091-6 | CAS number: 762-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: inhalation hazard test; no LD50 was derived
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- 200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.
- GLP compliance:
- not specified
- Test type:
- other: Inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl phosphonate
- EC Number:
- 212-091-6
- EC Name:
- Diethyl phosphonate
- Cas Number:
- 762-04-9
- Molecular formula:
- C4H11O3P
- IUPAC Name:
- diethyl phosphonate
- Test material form:
- other: colourless liquid
- Details on test material:
- content not given
the substance is described as technically pur; colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Fasting period before study: ca 16 hours
- Diet ad libitum:
- Water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no details given
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- 200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 7 h
- Concentrations:
- no data
inhalation hazard test - No. of animals per sex per dose:
- 5 males and 5 females at 20°C,
5 males and 5 females at 80°C - Control animals:
- no
- Details on study design:
- 200l air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed for a single period of 7 hours in a 10l vessel. The observation period was 14 days. Prior to treatment and weekly in the observation perieod the animals were weighed.. at the end of the study animals were examined gross-phathologically.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: inhalation hazard test
- Based on:
- other: exposure at 20°C and at 80°C
- Exp. duration:
- 7 h
- Remarks on result:
- other: The exposure was tolerated without signs of toxicity ; no rat died
- Mortality:
- no rat died
- Clinical signs:
- other: no rat showed clinical signs
- Body weight:
- normal body weight development
- Gross pathology:
- animals exposed at 20 °C showed no gross pathological changes
animals exposed at 80 °C showed mild swolen lungs at necropsy
Applicant's summary and conclusion
- Executive summary:
200 L air/hour were passed through ca 50 g of the substance at 20°C and at 80°C. In each case, 5 male and 5 female rats were whole-body exposed in a 10 L vessel for a single period of 7 hours. The observation period was 14 days. Prior to treatment and weekly in the observation period the animals were weighed. At the end of the study animals were examined gross-phathologically. No signs of toxicity were evident during exposure. No macroscopic effects were found in the 20°C group at post mortem at the end of the observation period, while mild swelling of the lungs were seen in animals in the 80°C group.
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