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Diss Factsheets
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EC number: 202-046-9 | CAS number: 91-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A long-term study of the test item to the freshwater planktonic crustacea, Daphnia magna, was conducted according to OECD guideline 211 (2012) and OECD Series Number 23: Guidance document on aquatic toxicity testing of difficult substances and mixtures. Since the test item is volatile, the study was carried out in a closed system without headspace (sealed glass flasks filled up to the top with the test solutions) under semi-static conditions with a daily renewal of the test solutions. The aim of the test was to assess the effects of the test item on the reproduction capacity and other sub-lethal effects of Daphnia magna. To this end, ten daphnids aged less than 24 hours (2 to 24 hours old) at the start of the test and held individually, were exposed to five concentration levels of the test item and the control. These test item concentrations were in a geometric series with a separation factor of 2.4, prepared by dilution of the saturated solution of the test item with dilution water as follows: 1.96 - 4.70 - 11.3 - 27.1 - 65.0% of the saturated solution.
These nominal concentrations for the definitive test were selected based on the results of a range finding test under semi-static conditions with daily water renewal over a duration of 10 days that corresponded to the appearance of the first brood. The test item concentrations were analytically verified via GC-MS in fresh media on days 0, 7, 14 (0 hours) and in old media on days 1, 8, 15 (24 hours) in all concentration levels and the control. Additionally, the saturated solution was analysed after preparation on day 0, 7 and 14 to show that the initial concentration is repeatable and stable.
Measured concentrations of the test item in fresh test media (0 hours) were in the range of 3.72 µg/L to 215 µg/L. At the end of the respective exposure intervals (24 hours), the measured concentrations in the old media were in the range of 2.59 to 147 µg/L, which corresponds to a range of 48 to 75% of the initially measured concentrations. Hence, for the evaluation in the present study, all effects levels were based on the geometric mean measured concentrations of the test item.
The overall effect threshold for effects of the test item under the test conditions was 56.7 µg/L (NOEC) and 143 µg/L (LOEC) based on the geometric mean measured concentrations of the test item.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 56.7 µg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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