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Diss Factsheets
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EC number: 200-441-0 | CAS number: 59-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity to fish
A 96-hour acute toxicity study according to EU Method C.1 and OCED Guideline 203 Acute Toxicity for Fish was carried out. Brown trout (Salmo Trutta Fario) were exposed to static concentrations of 1, 30, 300, 500, 600 and 1000 mg/L (nominal). The LC50 (96 h) was determined at 520 mg/L.
Acute toxicity to Daphnia
A 48 hour aquatic invertebrate toxicity test was carried out according to EU Method C.2 and OECD Guideline 202 (Method: DIN 38412 L11, Acute Toxicity for Daphnia). Daphnia magna were exposed in a static test over 48-hours to nominal concentrations of 18, 32, 58, 100, 180, 320, 580 mg/L. The 48-hour median effect concentration (EC50) for immobility, based on measured concentrations of test item, was found to be 77 mg/L (95 % confidence limits of 65 and 91 mg/L). The NOEC (EC0) after 48 h was determined 32 mg/L. The lowest measured concentration at which 100 % immobilization occurred after 48 h was 180 mg/L.
Toxicity to Algae
Two studies on algae toxicity were carried out according to EU Method C.3 and OECD Guideline 201 (Method: DIN 38412 L9, Algae Inhibition Test). Both studies were considered reliable with restrictions. The key study is well documented, including details on the test item, method and evaluation. Further, all raw data is included. The supporting study is less well documented. The study report does not include any details on the test material, only minimum information on the method used and no information on evaluation. Therefore, the selected key study is considered more reliable and results are used in hazard assessment.
In the key study Scenedesmus subspicatus was exposed for 72 h and 96 h to static concentrations of 0, 10, 25, 50 and 100 mg/L test item. The no-observed-effect concentration (NOEC) for growth rate and biomass was 25 mg/L. The 72 h 10 % effect concentrations for mean biomass (EbC10) and average specific growth rate (ErC10) respectively were found to be 29.6 mg/L (95 % confidence limits of 14.3 and 61.5 mg/L) and 38.18 mg/L (95 % confidence limits of 2.6 and 559.3 mg/L). The 72 h 50 % effect concentrations for mean biomass (EbC50) and average specific growth rate (ErC50) respectively were found to be 90.0 mg/L (95 % confidence limits of 29.7 and 272.5 mg/L) and 105.7 mg/L (95 % confidence limits of 1.9 and > 500 mg/L).
In the supporting study Scenedesmus subspicatus was exposed for 72 h and 96 h to static concentrations of 0, 10, 25, 50 and 100 mg/L test item. The 72 h 10 % effect concentrations for mean biomass (EbC10) and average specific growth rate (ErC10) respectively were found to be 4.3 mg/L (95 % confidence limits of 3.5 and 5.1 mg/L) and 12.1 mg/L (95 % confidence limits of 3.1 and 47.2 mg/L). The 72 h 50 % effect concentrations for mean biomass (EbC50) and average specific growth rate (ErC50) respectively were found to be 59.0 mg/L (95 % confidence limits of 37.3 and 93.3 mg/L) and 37.4 mg/L (95 % confidence limits of 4.1 and 338.9 mg/L).
Toxicity to microorganisms
A study equivalent or similar to EU Method C.11 and OECD Guideline 209 (Method according to Bringmann-Kuehn, Activated Sludge, Respiration Inhibition Test) was carried out. Pseudomonas putida was exposed to test item concentrations ranging from 15.63 - 500 mg/L over a period of 16 hours. The EC10 determined was 88 mg/L, the EC50 was 120 mg/L.
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