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EC number: 226-002-3 | CAS number: 5205-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
As a precautionary measure it is assumed that N-[3-Dimethylamino)propyl]methacrylamide may be a skin irritant.
N-[3-Dimethylamino)propyl]methacrylamide was demonstrated to be corrosive to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Range-finding study, test procedure in accordance with national standard method (US FHSA prodedure) with acceptable restrictions. 24 h exposure, observation period only 72 h
- Qualifier:
- according to guideline
- Guideline:
- other: according to Federal Hazardous Substances Act (FHSA) procedure
- Principles of method if other than guideline:
- FHSA PRIMARY SKIN IRRITATION/CORROSION
This study is designed to show the degree of skin irritation caused by the test article under evaluation. Six rabbits were used in the test. Twenty
four hours prior to dosing, the hair on each animal's back was removed with clippers. One inch square pieces of the test article were cut and
applied to intact and abraded areas on the skin of each animal. The squares of test article were held in place with surgical tape. To protect the
dosing sites and to promote occlusion, the trunks of each animal were wrapped with gauze, which was held in place with tape. The gauze was then wrapped with an elastic bandage.
After 24 hours, the animals were unwrapped and the article removed. The test sites were observed and scored 24 and 72 hours after dosing. Based on the scores, a Primary Irritation Index was calculated in order to evaluate the material's potential to be a primary irritant. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Dimethylaminopropyl Methacrylamide
- Molecular weight (if other than submission substance): 170.25 g/mol - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data - Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated skin areas of the test animals serve as the control (shaved, scarified).
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted 3-Dimethylaminopropyl methacrylamide - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24h and 72h post application
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back of the animals
- coverage: one inch square pieces
- Type of wrap if used:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): 24 hours after dosing
SCORING SYSTEM: Draize J.H. et al. (1944) (original values) - Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- intact and abraded skin; evaluation of erythema and edema
- Basis:
- mean
- Remarks:
- Draize score (Draize J.H. et al. 1944)
- Time point:
- other: 24 and 72 hours
- Score:
- 4.3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks:
- structure of tissue not destroyed or changed irreversibly in 24 hours. No formation of edema (intact skin).
- Remarks on result:
- other: Original data, evaluation according to Draize et al., 1944
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- intact skin; evaluation of erythema and edema
- Basis:
- mean
- Remarks:
- reevaluation according to GHS-criteria
- Time point:
- other: 24 and 72 hours
- Score:
- 2.8
- Max. score:
- 8
- Reversibility:
- no data
- Remarks:
- structure of tissue not destroyed or changed irreversibly in 24 hours. No formation of edema (intact skin).
- Remarks on result:
- other: GHS-category: 2
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact shaved skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- intact shaved skin, no scoring at 48 h
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- intact shaved skin, no scoring at 48 h
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- N-Dimethylaminopropylmethacrylamide is slightly irritating according to the Draize et al. (1944) scoring system.
The reevaluation of the study results according to GHS-criteria reveal to GHS-category: 2 for N-Dimethylaminopropylmethacryamide. Therefore
N-Dimethylaminopropylmethacrylamide would be classified as skin irritating according to GHS-criteria. - Executive summary:
In a primary dermal irritation study 6 rabbits (strain: no data, sex: no data) were dermally exposed via a covered patch (FHSA-procedure) to 0.5 ml undiluted (intact and abraded skin) Dimethylaminopropyl Methacrylamide (purity: >=98%) for 24 hours. Animals then were observed for 3 days. Irritation was scored by the method of Draize et al. 1944.
In this study, Dimethylaminopropyl Methacrylamide is not a dermal irritant as primary irritation score of 4.3 out of 8 is less than 5.0 evaluation
according to Draize et al., 1944.
Reference
Skin irritation scores (original data)
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Erythema (animals 1 -6) |
Edema (animals 1 -6) |
Max. score: 4 |
Max. score: 4 |
|
24 h intact skin 24 h scarified skin |
4/4/3/3/3/3 4/4/3/3/3/3 |
0/0/0/0/0/0 2/3/3/3/3/3 |
72 h intact skin 72 h scarified skin |
3/3/2/2/2/2 4/4/3/3/3/3 |
0/0/0/0/0/0 2/3/2/2/2/2 |
Average 24h, 72h intact skin Average 24h, 72h scarified skin |
2.8 3.3 |
0 2.5 |
Average 24h, 72h intact and scarified skin |
3.05 |
1.25 |
|
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Range-finding study, test procedure in accordance with national standard methods with acceptable restrictions.
- Guideline:
- other: according to Federal Hazardous Substances Act (FHSA) procedure
- Principles of method if other than guideline:
- In the FHSA test six eyes are exposed, but not rinsed. A fixed dose of 0.1 ml of Dimethylaminopropyl methacrylamide is used. This is placed inside the lower eyelid, which forms a culdesac. Ocular reactions are read either with the unaided eye or a magnifier at 24, 48 and 72 h after exposure. In
the FHSA test, no readings after 72 h are specified. Use of fluorescein after 24-h reading is optional in the FHSA version, but is not mentioned in
the Draize procedure. Readings are recorded as separate scores for lesions of the cornea, iris, and conjunctiva. Serious lesions such as pannus,
phlyctena, or ulceration of the cornea are considered to be off-scale responses that are to be noted separately. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Dimethylaminopropyl Methacrylamide
- Molecular weight (if other than submission substance): 170.25 g/mol - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eyes of the test animals serve as the control
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no removal of the test substance
SCORING SYSTEM: Draize J.H. et al. (1944) (original values) - Irritation parameter:
- other: Primary irritation index
- Basis:
- mean
- Remarks:
- according to Scoring system of Draize et al. 1944
- Time point:
- 24/48/72 h
- Score:
- 66.3
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- other: A corrosive-like action to the eye lids of 4 rabbits was determined. The iris could not be viewed because of corneal opacity in 3 of 4 rabbits.
- Remarks:
- Reversibility scores were not measured after 7 and 21 days.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 60
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 5
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irreversible damage to cornea, iris, conjunctiva 21 days after exposure in at least one animal
- Mean Draize score in 2 of 3 animals:
- Reversible adverse effects on cornea, iris, conjunctiva
- Mean Draize score in 2 of 3 animals:
- Reversible in 21 days
- Reversible in 7 days
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Dimethylaminopropyl methacrylamide has a corrosive-like action to the eye lids of 4 rabbits. Effects on the iris could not be evaluates in 3 of 4 rabbits due to severe corneal opacity.
Classification: risk of serious damage to eyes, GHS-category: 1, H318, causes serious eye damage - Executive summary:
In a primary eye irritation study, 0.1 mL of Dimethylaminopropyl methacrylamide (purity: >= 98%) was instilled into the conjunctival sac of 4 rabbits (strain, sex, source, age, weight: no data) for 72 hours. The eyes were not washed. Irritation was scored by the method of Draize et al. (1944).
In this study, Dimethylaminopropyl methacrylamide was a strong eye irritant. It was found to have a corrosive-like action to the eye lids of the rabbits and induced changes of the eye which were considered irreversible.
Based in EU and OECD criteria the DMAPMA is considered a category 1 eye irritant with the potential to cause irreversible damage to the eye.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Classification of eye irritation studies according GHS-criteria/original values
Substance: 3-Dimethylaminopropyl methacrylamide DMAPMA CAS: 5205-93-6
Internal No.: LITSU 96-0160
Date/Expert: 06-12-18/Am
Evaluation at the end of the table
Animal No. |
Corneal opacity/Hornhauttrübung[Scores] orignal values |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
60 |
60 |
60 |
|
|
|
|
2 |
80 |
80 |
80 |
|
|
||
3 |
80 |
80 |
80 |
|
|
|
|
4 |
80 |
80 |
80 |
|
|
|
|
|
|
|
|
|
|
|
|
Animal No. |
Iritis/Regenbogenhautentzündung[Scores] original values |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
5 |
5 |
5 |
|
|
|
|
2 |
0 |
0 |
0 |
|
|
||
3 |
0 |
0 |
0 |
|
|
|
|
4 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
Animal No. |
Conjunctiva /Bindehautrötung/ödem[Scores] original values |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
16 |
16 |
16 |
|
|
||
2 |
16 |
16 |
16 |
|
|
|
|
3 |
16 |
16 |
16 |
|
|
|
|
4 |
16 |
16 |
16 |
|
|
|
There
was a discernible opacity or ulceration of the cornea during the
readings made at 24, 48 or 72 hours. There
was an obvious swelling of the conjunctivae, excluding cornea and iris,
with partial eversion of the lids.There
was destruction or irreversible change at any tissue in 24 hours or less.
The iris could not be viewed because of corneal opacity in 3 of 4 rabbits.
A corrosive-like action to the eye lids of 4 rabbits. Corneal opacity in 3 of 4 rabbits!
Classification GHS: Hazard Category |
1 irreversible effects |
Classification Criteria for serious Eye Damage/Eye Irritation
Category 1
corneal opacity≥ 3
iritis ≥ 1,5
Category 2
corneal opacity≥1
iritis≥1
redness≥2
chemosis≥2
Subcategory 2A
Subcategory 2B
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
Two independent studies exist with similar experimental design (IBR (International Bio-Research Institute), 1983; Mellon Institute, Chemical Hygiene Fellowship (CHF), 1973). In both cases six rabbits were exposed under occlusive conditions to 0.5 ml of N-[3-Dimethylamino)propyl]methacrylamide on intact and abraded/scarified skin. For the evaluation only the test data with intact skin were taken into account. In both cases the dermal reaction was limited to erythema but the extent of irritation was very different. While in the first study (IBR (International Bio-Research Institute), 1983) only very slight erythema was observed which was completely reversible within 72 h, the other study ( Mellon Institute, Chemical Hygiene Fellowship (CHF), 1973) showed pronounced erythema (3 to 4) which was only partly reversible within the 72 h observation period.
Information available on test material and test design do not provide an explanation for the highly variable test results and in the absence of further information it cannot be excluded that the test material is irritating to skin. As a precautionary measure it is assumed that N-[3-Dimethylamino)propyl]methacrylamide may be a skin irritant.
Eye irritation
In a primary eye irritation study, 0.1 mL of Dimethylaminopropyl methacrylamide (purity: >= 98%) was instilled into the conjunctival sac of 4 rabbits (strain, sex, source, age, weight: no data) for 72 hours. The eyes were not washed. Irritation was scored by the method of Draize et al. (1944).
In this study, Dimethylaminopropyl methacrylamide was a strong eye irritant. It was found to have a corrosive-like action to the eye lids of the rabbits and induced changes to the eye which were considered irreversible.
Justification for selection of skin irritation / corrosion endpoint:
Two independent studies exist with similar experimental design (IBR (International Bio-Research Institute), 1983; Mellon Institute, Chemical Hygiene Fellowship (CHF), 1973). Information available on test material and test design do not provide an explanation for the highly variable test results and in the absence of further information it cannot be excluded that the test material is irritating to skin. As a precautionary measure it is assumed that N-[3-Dimethylamino)propyl]methacrylamide may be a skin irritant.
Justification for selection of eye irritation endpoint:
There is one relevant, adequate and reliable (Klimisch score = 2) study for N-[3-(dimethylamino)propyl]methacrylamide available (Mellon Institute, Chemical Hygiene Fellowship (CHF), 1973). The test was performed in accordance with generally accepted scientific standards and described in
sufficient detail. Guideline study with acceptable restrictions. GLP (no data).
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: corrosive
Justification for classification or non-classification
Under UN-GHS (2009) and CLP/EU-GHS, EG Regulation No. 1272/2008 DMAPMA has to be classified as follows: Skin irritation cat. 2, H315; Eye damage cat. 1, H318, Causes serious eye damage
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