Registration Dossier
Registration Dossier
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EC number: 236-826-5 | CAS number: 13499-05-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro mutagenicity: on the basis of annex XI-1, testing is scientifically not justified: bacterial mutagenesis assays of inorganic metal compounds are frequently negative due to limited capacity for uptake of metal ions. The high prevalence of false negatives for metal compounds might suggest that mutagenesis assays with mammalian cells, as opposed to bacterial cells, would be the preferred starting point for testing for this class of Annex VII substances.
But, as the registered substance is not stable and degrades instantaneously, testing for genotoxicity in general is not possible. The substance needs to be estimated considering the toxicity of its degradation products. HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects. ZrO2 was especially tested in vitro with bacteria and mamalian cells and all tests were negative for genotoxicity (Ames, mouse lymphoma assay, chromosomic aberation and comet assay).
HCl is not classified for genotoxicity (REACh 2010 registration).
For all these reasons, no study was performed for genotoxicity with HfCl4 and all concerned endpoints are waived.
Endpoint Conclusion:
Justification for classification or non-classification
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for genotoxicity is for this reason not relevant at all, in the same way, no classification is needed.
Nevertheless, degradation products have to be considered, and they are already classified :
- Hydrogen chloride was registered in the frame of REACh in 2010, and is not classified for genotoxicity,
- HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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