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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study not performed according to GLP, no details provided regarding experimental design (doses, number of animals) and observation only for 7 days, but data are well documented and scientifically acceptable.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
The toxicologic and pharmacologic effects of hafnium salts
Author:
Haley TJ, Raymond K, Komesu N, Upham HC
Year:
1962
Bibliographic source:
Toxicology and applied pharmacology 4, 238-246

Materials and methods

Principles of method if other than guideline:
No details available on method. The acute toxicity was investigated by intraperitoneal route for 7 days.
GLP compliance:
no
Test type:
other: intraperitoneal LD50

Test material

Constituent 1
Reference substance name:
Hafnyl chloride (HfOCl2)
IUPAC Name:
Hafnyl chloride (HfOCl2)
Details on test material:
hafnium chloride 98.5% purity, no other details

Test animals

Species:
mouse
Strain:
CF-1
Sex:
male

Administration / exposure

Route of administration:
other: intraperitoneal
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
total number of animals: 86
Control animals:
not specified
Details on study design:
observation of the animals for 7 days after the administration of hafnyl chloride

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
112 mg/kg bw
Based on:
not specified
95% CL:
93.3 - 134.4
Mortality:
The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.
Clinical signs:
other: The symptoms of acute toxicity were immediate urination and lethargy.

Applicant's summary and conclusion

Executive summary:

The intraperitoneal LD50was determined on 86 male CF-1 mice and was found to be 112 mg/kg (93.3-134.4) for hafnyl chloride (HfOCl2), for 7 days. The symptoms of acute toxicity were immediate urination and lethargy. The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.