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EC number: 225-969-9 | CAS number: 5188-07-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- Molecular formula:
- CH4S.Na
- IUPAC Name:
- sodium methylsulfanide
- Details on test material:
- Test article name : Sodium methylmercaptide
CAS RN°: 5188-07-8
Origin: Elf Atochem NA
Batch: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Myrtle's rabbitry, Thompson Station, TN, USA
- Age at study initiation: adult
- Weight at study initiation: 2.3 to 2.5 kg
- Housing: individually in suspended stainless steel cages
- Diet (ad libitum): PMI certified rabbit chow #5322
- Water (ad libitum): municipal tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 69-71
- Humidity (%): 26-33
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Concentration: 21 % active substance
- Duration of treatment / exposure:
- 3 minutes and 1 hour
- Observation period:
- 1 and 24 hours
- Number of animals:
- 6
- Details on study design:
- The potential irritant and/or corrosive effects of Sodium Methyl Mercaptide were evaluated on the skin of New Zealand White rabbits. Each rabbits received a 0.5 mL dose of the test article as a single dermal application. The dose was held in contact with the skin under a semi-occlusive binder for an exposure period of three minutes (6 rabbits) or 1 hour (one rabbit). Following the exposure periods, the gauze patch and/or binder were removed and the remaining test article was wiped from the skin using gauze moistened with deionized water. Test sites were evaluated for potential in-depth injury immediately following patch removal, one hour following patch removal and 24 hours following patch application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Necrosis
- Basis:
- other: All animals
- Time point:
- other: 3 min, 1 and 24 hours
- Reversibility:
- not reversible
- Remarks on result:
- other: 3-min exposure
- Irritation parameter:
- other: Necrosis
- Basis:
- other: One animal
- Time point:
- other: 1 and 24 hours
- Reversibility:
- not reversible
- Remarks on result:
- other: 1-hour exposure
- Irritant / corrosive response data:
- Exposure to the test article for a three-minute exposure period produced necrosis (grades 1-4) and blanching (grades 3-4) on 6/6 test sites by the one hour scoring interval. At the 24 hour scoring interval, necrosis (grades 1-2) was noted on 5/6 test sites and blanching (grades 2-4) and eschar (grades 1-3) were noted on 6/6 test sites.
Exposure to the test article for a one-hour exposure period produced necrosis (grade 4) and moderate edema on the test sites by the one hour scoring interval. In addition, the outer most layer of skin appeared to be sloughing off and this animal exhibited increased activity and labored breathing shortly after dosing. At the 24 hour scoring interval, eschar (grade 4) and severe edema were noted on the test site.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272-2008
- Conclusions:
- The test substance is considered to be corrosive to the skin of the rabbit after a three-minute exposure period.
- Executive summary:
A primary skin irritation study using New Zealand White rabbits was performed with a 21% solution of sodium methanethiolate in water according to the OECD Test Guideline 404. Six rabbits received a 0.5 ml dose of the solution as a single dermal application under semi-occlusive conditions for 3 minutes. At one hour, necrosis (grades 1-4) and blanching (grades 3-4) were observed at all 6 sites. At 24 hours post-dose, 5/6 test sites were observed with necrosis (grades 1-2) and 6/6 test sites were blanched (grades 2-4) and had eschar (grades 1-3). Sodium methanethiolate, in a 21% aqueous solution, was determined to be corrosive, causing severe burns, to rabbit skin following a 3-minute exposure.
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