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Reaction mass of Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[[2-(sulfooxy)Vinyl]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)], trisodium salt and Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)]-, sodium and Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[2-(sulfooxy)Ethanol]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)], trisodium salt
EC number: 941-883-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From July 5 to 8,1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Complete read across justification is attached in section 13. Source study has reliability 1.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- yes
Test material
- Reference substance name:
- RA Substance 01
- IUPAC Name:
- RA Substance 01
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG
- Weight at study initiation: 2.8 - 3.6 kg
- Housing: in a climatised room, inside a standard cage
- Diet : Altromin 2013 Zuchtdiat, ad libitum
- Water : deionized water with chloride, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20 ± 2 °C
- Humidity: 55 ± 10 %
- Photoperiod: 12 hrs cycle dark/light
Test system
- Vehicle:
- physiological saline
- Remarks:
- to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL: 100 mg.
VEHICLE: 0.01 ml physiological saline. - Duration of treatment / exposure:
- 24 hours.
- Observation period (in vivo):
- 72 hours.
- Number of animals or in vitro replicates:
- 3.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing : yes, with warm physiological saline
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize
CORNEA
Degree of turbidity (reading in the area of the strongest turbidity)
0 No turbidity, no ulceration
1* Turbidity on individual scattered districts, details of the iris clearly visible
2* Easily recognizable translucent regions of turbidity, details of iris slightly darkened
3* Turbidity of pearly-like appearance, no details of the iris can be seen, size of the pupil barely visible
4* Complete corneal opacity, iris not visible
IRIS
1* Conspicuously deep retracted folds, hyperemia, swelling, circumcorneal vascular symptoms (one of these symptoms or combinations of them), iris still responds to light (slow response = positive)
2* No reaction to light, bleeding, destruction of iris (some or all symptoms)
CONJUNCTIVA
redness
0 Vessels normal
1 Vessels clearly injected (hyperemia)
2* Diffuse ruby redness, single vessels not easy to distinguish
3* Diffuse fleshy redness
chemosis
0 No swelling
1 Slight swelling (including throat)
2* Distinct swelling, partial lifting of the lid
3* Swelling, with eyelids half-closed
4* Swelling, eyelids being closed more than half to full
* means positive effect
TOOL USED TO ASSESS SCORE: UV-light, fluorescein (0.01 %) and slit-lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: no ocular effect observed
- Irritation parameter:
- iris score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: no ocular effects observed
- Irritation parameter:
- chemosis score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: no ocular effects observed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: no ocular effects observed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- The conjunctiva at 1 h was blue discoloured.
Any other information on results incl. tables
time post-application | animal | cornea opacity | iris | conjuctivae redness | conjunctivae chemosis |
1 h | 1 | 0 | 0 | 1 | 1 |
2 | 0 | 0 | 0 | 1 | |
3 | 0 | 0 | 1 | 1 | |
24 h | 1 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 1 | 0 | |
3 | 0 | 0 | 1 | 0 | |
48 h | 1 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 0 | |
3 | 0 | 0 | 0 | 0 | |
72 h | 1 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 0 | |
3 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- The substance is considered as not irritant to the eye of rabbits.
- Executive summary:
Method
Test substance was applied to rabbit eye according to OECD guideline 405. After 24 h exposure, observations were done at 1, 24, 48 and 72 h after eye rinse.
Results
2 of 3 rabbits showed vessels clearly injected (hyperemia) 24 h after eye rinse. However, such effects were reversible within 48 hours. Consequently, test substance was considered as non irritant to rabbit eyes.
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