Santicizer 2148

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1990-02-01 to 1990-02-19

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

The test was conducted prior to the existence of the guideline.

Deviations:

not applicable

GLP compliance:

yes

Other quality assurance:

other: TSCA GLP Standard 40 CFR Part 792

Remarks:

test substance characterisation and stability data were not developed in accordance with the standard; reference substance characterisation and stability data were not developed in accordance with the standard

Type of method:

other: saturated column

Key result

Water solubility:

< 0.027 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

7

Table 1. Results for Saturator Column containing XP-2563
Flow Rate (mL/min)	Volume (mL)	mg/L Triphenyl Phosphate	Std. Dev	% Relative Std. Dev
1.0	50	0.149	0.019	13%
1.0	100	0.162	0.025	15%
1.5	60	0.141	0.049	35%
1.5	90	0.146	0.045	31%
1.5	60	0.153	0.027	18%
1.5	106	0.154	0.039	25%

Conclusions:

The aqueous solubility observed for the major components of the test material, dodecyl diphenyl phosphate and tetradecyl diphenyl phosphate, were less than the lowest validation concentration of the test material. This indicated that the aqueous solubility for dodecyl diphenyl phosphate is less than 0.025 mg/L. 
 
The method was validated down to 0.033 mg/L of the test material in water. Based on the percentage composition of the test material, this corresponded to 0.027 mg/L of dodecyl diphenyl phosphate which could not be detected in the water generated by the saturator column technique used in this experiment thereby indicating the aqueous solubility was less than 0.027 mg/L.

Executive summary:

The aqueous solubility of the test material (XP-2563) in water was evaluated in a key study at ambient temperature. The major components of XP-2563 are docecyl diphenyl phosphate, tetradecyl diphenyl phosphate, didoceyl phenyl phosphate, and triphenyl phosphate.

 

0.25 g of the test material was weighed into an Erlenmeyer flask to which 50 mL of methylene chloride was added. This mixture was transferred to a round bottom flask and 5 g of Chromosorb W was added subsequent to which the flask was connected to a rotary evaporator and water aspirator and evaporated until Chromosorb W was dry. The saturator column was flushed with 100 mL water while varying flow rate and the volume of water was collected. Samples were run in triplicate and % relative standard deviation was calculated for each set of samples collected at different flow rates and volumes.

 

The aqueous solubility observed for the major components of the test material, dodecyl diphenyl phosphate and tetradecyl diphenyl phosphate, were less than the lowest validation concentration of the test material. This indicated that the aqueous solubility for dodecyl diphenyl phosphate is less than 0.025 mg/L. 

 

The method was validated down to 0.033 mg/L of the test material in water. Based on the percentage composition of the test material, this corresponded to 0.027 mg/L of dodecyl diphenyl phosphate which could not be detected in the water generated by the saturator column technique used in this experiment thereby indicating the aqueous solubility was less than 0.027 mg/L.

Description of key information

The aqueous water solubility of the test material plasticizer XP-2563 at 20°C was determined to be less than 0.027 mg/L.

Key value for chemical safety assessment

Water solubility:

0.027 mg/L

at the temperature of:

20 °C

Additional information

The aqueous solubility of the test material (XP-2563) in water was evaluated in a key study at ambient temperature (Monsanto Company, 1990a).

 

0.25 g of the test material was weighed into an Erlenmeyer flask to which 50 mL of methylene chloride was added. This mixture was transferred to a round bottom flask and 5 g of Chromosorb W was added subsequent to which the flask was connected to a rotary evaporator and water aspirator and evaporated until Chromosorb W was dry. The saturator column was flushed with 100 mL water while varying flow rate and the volume of water was collected. Samples were run in triplicate and % relative standard deviation was calculated for each set of samples collected at different flow rates and volumes.

 

The aqueous solubility observed for the major components of the test material were less than the lowest validation concentration of the test material. This indicated that the aqueous solubility for the major component was less than 0.025 mg/L. 

 

The method was validated down to 0.033 mg/L of the test material in water. Based on the percentage composition of the test material, this corresponded to 0.027 mg/L of the major component which could not be detected in the water generated by the saturator column technique used in this experiment thereby indicating the aqueous solubility was less than 0.027 mg/L.