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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-05-03 to 1999-06-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- DRAFT document, July 1997
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Type of method:
- HPLC estimation method
- Media:
- sewage sludge
- Radiolabelling:
- not specified
- Test temperature:
- 35°C
- Details on study design: HPLC method:
- A HPLC with a spectrophotometric detector set to read the absorbances at 210 nm. The stationary phase was a cyanopropyl chemically bound resin on silica basis (Hypersil BDS-CN). The mobile phase was 55/45 (v/v) methanol/Milli-Q water. A temperature-controlled column compartment at 35°C was used.
Stock solutions of the reference substances (see Table) in methanol at concentrations between 1.1 g/L and 1.8 g/L were used. For calibration, each stock solution was diluted by a factor 100 with methanol.
A 2.3 g/L solution of formamide in methanol was diluted by a factor 10 with methanol. This solution was used for the determination of t0 (retention time of the unretarded component).
A 1.3 g/L test solution of Santicizer 2148 plasticizer was prepared in methanol.
The solutions were injected in the following sequence: nine reference substance solutions; methanol, formamide solution; test solution (in duplicate), methanol, nine reference substance solutions, and the formamide solution. The chromatograms of the test solution and formamide were recorded for 5 to 10 minutes. The chromatograms of the test solution were recorded for 25 or 35 minutes. The chromoatograms of methanol were recorded for 10 to 35 minutes. - Key result
- Type:
- log Koc
- Value:
- >= 6.1 - <= 7.3 dimensionless
- Temp.:
- 35 °C
- Remarks on result:
- not measured/tested
- Details on results (HPLC method):
- In the HPLC chromatograms of SANTICIZER 2148 PLASTICIZER, using detection at 210 nm and 55/45 (v/v) methanol/Milli-Q water as mobile phase, one large broad band and two small test substances peaks were observed. It was assumed that the small peaks derive from impurities in the test substance and that the broad derives from the five phosphoric acid esters,
The t0 was determined to be 2.05 minutes as a mean value of both measurements (i.e. 2.10 and 2.00 minutes) - Validity criteria fulfilled:
- not specified
- Conclusions:
- For the five phosphoric acid esters, the log KOC and KOC were given as a range of 6.1 - 7.3 and (0.13 - 2.0)*10^7, respectively.
- Executive summary:
The adsorption coefficient (KOC) in soil and on sewage sludge was estimated using HPLC. According to the information supplied by the sponsor, SANTICIZER 2148 PLASTICIZER is a mixture of five organic esters prepared from phosphoric acid. For the five phosphoric acid esters, the log KOC and KOC were given as a range of 6.1 - 7.3 and (0.13-2.0)*107, respectively.
Reference
Table 1 shows the determination of log KOCand KOCof SANTICIZER 2148 PLASTICIZER using 55/45 (v/v) methanol/Milli-Q waters as the mobile phase
Substance |
tr1 |
k’ |
log k’ |
log KOC |
KOC |
Reference substance |
|||||
Phenol |
2.233 |
0.09 |
-1.051 |
1.32 |
|
N,N-dimethylbenzamide |
2.226 |
0.09 |
-1.069 |
1.52 |
|
Methylbenzoate |
2.421 |
0.18 |
-0.744 |
1.80 |
|
3,5-Dinitrobenzamide |
2.402 |
0.17 |
-0.767 |
2.31 |
|
Naphtalene |
2.944 |
0.44 |
-0.361 |
2.75 |
|
Mercaptodimethur |
2.692 |
0.31 |
-0.505 |
3.10 |
|
Fenthion |
3.729 |
0.82 |
-0.087 |
3.31 |
|
Phenantrene |
3.630 |
0.77 |
-0.113 |
4.09 |
|
2,4-DDT |
5.581 |
1.72 |
0.236 |
5.63 |
|
Test substance |
|||||
Peak 1 (impurity) |
2.251 |
0.10 |
-1.011 |
1.22 |
16 |
Peak 2 (impurity) |
3.281 |
0.60 |
-0.222 |
3.83 |
6.3*103 |
Start band (major components) |
8.52 |
3.20 |
0.505 |
6.12 |
1.3*106 |
End band (major components) |
17.65 |
7.61 |
0.881 |
7.32 |
2.0*107 |
1 mean value of the retention times of two chromatograms
2 extrapolated from the regression line: log K’= 0.3122 log K‘OC-1.3915 (r=0.946, n=9)
3 interpolated from the regression line: log K’= 0.3122 log K’OC-1.3915 (r=0.946, n=9)
Description of key information
For the five phosphoric acid ester components of Santicizer 2148, the log KOC and KOC were determined to be in the range of 6.1 - 7.3 and (0.13 - 2.0)*107, respectively.
Key value for chemical safety assessment
Additional information
The adsorption coefficient (KOC) in soil and on sewage sludge was estimated using HPLC (NOTOX B.V., 1999i). According to the information supplied by the sponsor, SANTICIZER 2148 PLASTICIZER is a mixture of five organic esters prepared from phosphoric acid. For the five phosphoric acid esters, the log KOC and KOC were given as a range of 6.1 - 7.3 and (0.13 - 2.0)*107, respectively.
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