Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-246-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Two key studies of skin irritation plus three of eye irritation are identified (all rabbit studies performed in vivo).
Skin irritation: both studies found signs of local reaction, including erythema and oedema . In one case, up to grade 3 erythema and grade 3 oedema were seen but persistence of the reactions was insufficient to trigger classification. In the other case, generally similar reactions were seen (slightly more marked erythema, slightly less oedema) but these persisted longer leading to mean scores and unresolved (slight) erythema sufficient to warrant classification.
Eye irritation: the observed (transient) ocular reactions in all key studies were insufficient to warrant classification.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
No animal test of respiratory irritation has been identified. Falk AA et al. (Scand. J. Work Environ. Health 16: 372-8, 1990) reported that 5 of 8 human volunteers exposed to alpha-pinene by inhalation (2h exposures during light exercise) at 450 mg/cu.m reported irritation of the eyes, nose and throat: however no significant change in lung function was found after exposure, with no indication of bronchoconstriction.
Falk Filipsson, Bard and Karlsson (CICAD 5 – Limonene, WHO 1998) noted that 8 human subjects exposed by inhalation to d-limonene (2h at up to 450 mg/cu.m) reported no discomfort or irritation. Taken together with the skin and eye irritation reported here, these data for close analogues of pinene oligomers do not provide sufficient evidence to designate pinene oligomers as a respiratory irritant.
Effects on skin irritation/corrosion: irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Consideration of the key study animal test data against EU classification and labelling criteria lead to the conclusion that pinene oligomers is irritating to the skin but not to eyes.
While the available data are not conclusive, no evidence indicating classification as a respiratory irritant has been identified.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
