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EC number: 219-247-2 | CAS number: 2393-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity: Oral
Repeated dose oral toxicity was predicted for 4-Methoxybenzylamine using data from structurally and functionally similar read across chemicals. The studies are as mentioned below:
Chronic toxicity oral study for the 70 -80% structurally and functionally similar test compound was studied in male and female Osborne-Mendel rats. The test compound was fed through the diet at a concentration of 0 or 1000 ppm (0 or 50 mg/Kg bw) for 15 weeks. The animals were observed weekly for weight, food intake and general condition. Haematological examinations were made at termination. These examinations included white cell counts, red cell counts, haemoglobins and haematocrits. No effects were noted in the treated animals at the mentioned dose level. Based on the observations made, the no observed Adverse Effect Level (NOAEL) for the test compound in Osborne-Mendel rats is found to be 50 mg/Kg bw.
Combined repeated dose- carcinogenicity study was also conducted for 60 -70% structurally and functionally similar read across chemical using male and female mice of strain B6C3F1 for 18 months. The chemical was used at dose levels of 0 or 215 mg/Kg and given daily for 18 months. Oral administration by stomach tube was initiated from 7th day of age to 28th weanling day following which the compound was mixed with the ground feed. Animals were observed daily for any abnormalities and palpated weekly at time of weighing for enlargement of liver and spleen. Animals which appeared moribund were killed for necropsy. One mice of each sex died during the 18 months experimental study period. Significant weight gain was observed with the increase in duration from 4, 26, 52 weeks to 18 months. Incidence of Type A Reticulum cell carcinoma and Hepatic carcinoma with kidney metastasis was observed in 1 male animal each and Pulmonary adenoma was noted in 2 female mice. Based on the observations made, No Observed Adverse Effect Level (NOAEL) for the test chemical is considered to be <215 mg/Kg.
Based on the data summarized for the structurally and functionally similar read across chemicals, 4-Methoxybenzylamine is not likely to be toxic as per the criteria mentioned in CLP regulation.
Repeated dose toxcity: Inhalation
(4-methoxyphenyl)methanamine has very low vapor pressure of 0.2 mm Hg at 50˚C, so the potential for the generation of inhalable vapours is very low. Also the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore this end point for repeated dose toxicity by inhalation route is considered for waiver.
Repeated dose toxicity: Dermal
The substance 4-methoxyphenyl)methanamine is considered to be corrosive to skin. No repeated dose dermal toxicity studies for the target chemical are available based on the corrosive nature of the test chemical. Based on these considerations, the end point for repeated dermal toxicity is considered as waiver.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- Quality of whole database:
- Data is from K2 prediction database
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation, other
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Quality of whole database:
- Waiver
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Quality of whole database:
- Waiver
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated dose toxicity: Oral
Repeated dose oral toxicity was predicted for 4-Methoxybenzylamine using data from structurally and functionally similar read across chemicals. The studies are as mentioned below:
Chronic toxicity oral study for the 70 -80% structurally and functionally similar test compound was studied in male and female Osborne-Mendel rats. The test compound was fed through the diet at a concentration of 0 or 1000 ppm (0 or 50 mg/Kg bw) for 15 weeks. The animals were observed weekly for weight, food intake and general condition. Haematological examinations were made at termination. These examinations included white cell counts, red cell counts, haemoglobins and haematocrits. No effects were noted in the treated animals at the mentioned dose level. Based on the observations made, the no observed Adverse Effect Level (NOAEL) for the test compound in Osborne-Mendel rats is found to be 50 mg/Kg bw.
Combined repeated dose- carcinogenicity study was also conducted for 60 -70% structurally and functionally similar read across chemical using male and female mice of strain B6C3F1 for 18 months. The chemical was used at dose levels of 0 or 215 mg/Kg and given daily for 18 months. Oral administration by stomach tube was initiated from 7th day of age to 28th weanling day following which the compound was mixed with the ground feed. Animals were observed daily for any abnormalities and palpated weekly at time of weighing for enlargement of liver and spleen. Animals which appeared moribund were killed for necropsy. One mice of each sex died during the 18 months experimental study period. Significant weight gain was observed with the increase in duration from 4, 26, 52 weeks to 18 months. Incidence of Type A Reticulum cell carcinoma and Hepatic carcinoma with kidney metastasis was observed in 1 male animal each and Pulmonary adenoma was noted in 2 female mice. Based on the observations made, No Observed Adverse Effect Level (NOAEL) for the test chemical is considered to be <215 mg/Kg.
Based on the data summarized for the structurally and functionally similar read across chemicals, 4-Methoxybenzylamine is not likely to be toxic as per the criteria mentioned in CLP regulation.
Repeated dose toxcity: Inhalation
(4-methoxyphenyl)methanamine has very low vapor pressure of 0.2 mm Hg at 50˚C, so the potential for the generation of inhalable vapours is very low. Also the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore this end point for repeated dose toxicity by inhalation route is considered for waiver.
Repeated dose toxicity: Dermal
The substance 4-methoxyphenyl)methanamine is considered to be corrosive to skin. No repeated dose dermal toxicity studies for the target chemical are available based on the corrosive nature of the test chemical. Based on these considerations, the end point for repeated dermal toxicity is considered as waiver.
Based on the data available for thetarget chemical and its read across, (4-methoxyphenyl)methanamine (CAS no 2393 -23 -9) is not likely to be toxic upon repeated exposure by oral route as per the criteria mentioned in CLP regulation.
Justification for classification or non-classification
Based on the data available for thetarget chemical and its read across, (4-methoxyphenyl)methanamine (CAS no 2393 -23 -9) is not likely to be toxic upon repeated exposure by oral route as per the criteria mentioned in CLP regulation.
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