Registration Dossier
Registration Dossier
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EC number: 204-465-2 | CAS number: 121-33-5
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not enough data for assessment, in Russian language.
Data source
Reference
- Reference Type:
- publication
- Title:
- Problem of the toxicity of vanillin
- Author:
- Makaruk MI
- Year:
- 1 980
- Bibliographic source:
- Gig Sanit, 6, 78-80
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- no data
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.5 mg/m³ air
- Dose / conc.:
- 1.5 mg/m³ air
- Dose / conc.:
- 15 mg/m³ air
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- no data
- Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Details on results:
- Long-term inhalation of vanillin at 15.0 mg/m3 affected the nervous and cardiovascular systems and the functional activity of the liver, adrenal
glands, and blood system.
Vanillin at 1.5 mg/m3 is close to the threshold level for activity and at 0.5 mg/m3, vanillin is inactive on the systems tested.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 0.001 other: mg/l
- Sex:
- not specified
- Dose descriptor:
- LOAEL
- Effect level:
- 0.002 - 11 mg/L air
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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