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EC number: 308-208-6 | CAS number: 97925-95-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Analytical monitoring:
- yes
- Endpoint:
- long-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- GLP compliance:
- no
- Remarks:
- calculation
- Test organisms (species):
- other: freshwater fish
- Test type:
- other: calculation
- Total exposure duration:
- 28 d
- Duration:
- 28 d
- Dose descriptor:
- other: geometric mean of LOEC and NOEC
- Effect conc.:
- 0.039 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Atmer 163 (C13): based on calculation
- Duration:
- 28 d
- Dose descriptor:
- other: geometric mean of NOEC and LOEC
- Effect conc.:
- 0.012 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Atmer 163 (C15): based on calculation
Referenceopen allclose all
ECOSAR program (v1.00) Results:
=====================================================
Atmer 163 (C13)
SMILES : CCCCCCCCCCCCCN(CCO)(CCO)
MOL FOR: C17 H37 N1 O2
MOL WT : 287.49
Log Kow: 4.39 (KowWin estimate)
Wat Sol: 81 mg/L (measured)
ECOSAR v1.00 Class(es) Found
------------------------------
Aliphatic Amines
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Aliphatic Amines : Fish 96-hr LC50 1.841
Aliphatic Amines : Daphnid 48-hr LC50 0.304
Aliphatic Amines : Green Algae 96-hr EC50 0.284
Aliphatic Amines : Fish ChV 0.039
Aliphatic Amines : Daphnid ChV 0.020
Aliphatic Amines : Green Algae ChV 0.060
Aliphatic Amines : Fish (SW) 96-hr LC50 2.005
Aliphatic Amines : Mysid Shrimp (SW) 96-hr LC50 0.273
Aliphatic Amines : Green Algae (SW) 96-hr EC50 0.276
Aliphatic Amines : Fish (SW) ChV 0.039
Aliphatic Amines : Mysid Shrimp (SW) ChV 0.020
Aliphatic Amines : Green Algae (SW) ChV 0.061
=========================== ================== ======== ====== ==========
Neutral Organic SAR : Fish 96-hr LC50 2.100
(Baseline Toxicity) : Daphnid 48-hr LC50 1.618
: Green Algae 96-hr EC50 1.860
: Fish ChV 0.189
: Daphnid ChV 0.228
: Green Algae ChV 1.042
Note: * = asterisk designates: Chemical may not be soluble
enough to measure this predicted effect.
Aliphatic Amines:
----------------
For Fish 96-hr LC50: For aliphatic amines with log Kow greater than 7.0,
a test duration of greater than 96 hrs may be required for proper
expression of toxicity. Also, if the toxicity value obtained by the use
of this equation exceeds the water solubility (measured or estimated),
mortalities greater than 50% would not be expected in a saturated
solution during an exposure period of 96 hrs.
For Daphnid 48-hr LC50: For aliphatic amines with log Kow greater than
5.0, a test duration of greater than 48 hrs may be required for proper
expression of toxicity. Also, if the toxicity value obtained by the use
of this equation exceeds the water solubility (measured or estimated),
significant mortalities would not be expected in a saturated solution
during an exposure period of 48 hrs.
For Green Algae Acute Toxicity Values: If the log Kow of the chemical is
greater than 7, or if the compound is solid and the EC50 exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For Mysid Shrimp Acute Toxicity Values: If the log Kow of the chemical is
greater than 6, or if the compound is solid and the EC50 exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For Fish and Daphnid Chronic Toxicity Values: If the log Kow of the chemical
is greater than 8.0, or if the compound is solid and the ChV exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For Green Algae Chronic Toxicity Values: If the log Kow of the chemical
is greater than 7.0, or if the compound is solid and the ChV exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
ECOSAR v1.00 SAR Limitations:
----------------------------
Maximum LogKow: 6.0 (Fish, Mysid LC50)
Maximum LogKow: 5.0 (Daphnid LC50)
Maximum LogKow: 7.0 (Green Algae EC50)
Maximum LogKow: 8.0 (Fish, Daphnid ChV)
Maximum LogKow: 7.0 (Green Algae ChV)
Maximum Mol Wt: 1000
Baseline Toxicity SAR Limitations:
---------------------------------
Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)
Maximum LogKow: 6.4 (Green Algae EC50)
Maximum LogKow: 8.0 (ChV)
Maximum Mol Wt: 1000
===========================================================
Atmer 163 (C15)
SMILES : CCCCCCCCCCCCCCCN(CCO)(CCO)
MOL FOR: C19 H41 N1 O2
MOL WT : 315.54
Log Kow: 5.37 (KowWin estimate)
Wat Sol: 81 mg/L (measured)
ECOSAR v1.00 Class(es) Found
------------------------------
Aliphatic Amines
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Aliphatic Amines : Fish 96-hr LC50 0.518
Aliphatic Amines : Daphnid 48-hr LC50 0.105
Aliphatic Amines : Green Algae 96-hr EC50 0.135
Aliphatic Amines : Fish ChV 0.012
Aliphatic Amines : Daphnid ChV 0.018
Aliphatic Amines : Green Algae ChV 0.022
Aliphatic Amines : Fish (SW) 96-hr LC50 0.569
Aliphatic Amines : Mysid Shrimp (SW) 96-hr LC50 0.092
Aliphatic Amines : Green Algae (SW) 96-hr EC50 0.130
Aliphatic Amines : Fish (SW) ChV 0.012
Aliphatic Amines : Mysid Shrimp (SW) ChV 0.018
Aliphatic Amines : Green Algae (SW) ChV 0.023
=========================== ================== ======== ====== ==========
Neutral Organic SAR : Fish 96-hr LC50 0.340
(Baseline Toxicity) : Daphnid 48-hr LC50 0.295
: Green Algae 96-hr EC50 0.508
: Fish ChV 0.030
: Daphnid ChV 0.049
: Green Algae ChV 0.340
Note: * = asterisk designates: Chemical may not be soluble
enough to measure this predicted effect.
Aliphatic Amines:
----------------
For Fish 96-hr LC50: For aliphatic amines with log Kow greater than 7.0,
a test duration of greater than 96 hrs may be required for proper
expression of toxicity. Also, if the toxicity value obtained by the use
of this equation exceeds the water solubility (measured or estimated),
mortalities greater than 50% would not be expected in a saturated
solution during an exposure period of 96 hrs.
For Daphnid 48-hr LC50: For aliphatic amines with log Kow greater than
5.0, a test duration of greater than 48 hrs may be required for proper
expression of toxicity. Also, if the toxicity value obtained by the use
of this equation exceeds the water solubility (measured or estimated),
significant mortalities would not be expected in a saturated solution
during an exposure period of 48 hrs.
For Green Algae Acute Toxicity Values: If the log Kow of the chemical is
greater than 7, or if the compound is solid and the EC50 exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For Mysid Shrimp Acute Toxicity Values: If the log Kow of the chemical is
greater than 6, or if the compound is solid and the EC50 exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For Fish and Daphnid Chronic Toxicity Values: If the log Kow of the chemical
is greater than 8.0, or if the compound is solid and the ChV exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
For Green Algae Chronic Toxicity Values: If the log Kow of the chemical
is greater than 7.0, or if the compound is solid and the ChV exceeds the water
solubility by 10X, no effects at saturation are predicted for these endpoints.
ECOSAR v1.00 SAR Limitations:
----------------------------
Maximum LogKow: 6.0 (Fish, Mysid LC50)
Maximum LogKow: 5.0 (Daphnid LC50)
Maximum LogKow: 7.0 (Green Algae EC50)
Maximum LogKow: 8.0 (Fish, Daphnid ChV)
Maximum LogKow: 7.0 (Green Algae ChV)
Maximum Mol Wt: 1000
Baseline Toxicity SAR Limitations:
---------------------------------
Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)
Maximum LogKow: 6.4 (Green Algae EC50)
Maximum LogKow: 8.0 (ChV)
Maximum Mol Wt: 1000
Description of key information
The Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the chronic toxicity of Atmer 163 to fish.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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