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EC number: 200-875-0 | CAS number: 75-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not according to guideline and not GLP but provides basic repeated exposure toxicity data.
Data source
Reference
- Reference Type:
- publication
- Title:
- On the toxic effect of low trimethylamine concentrations
- Author:
- Rotenberg, I., and Mashbits, F.
- Year:
- 1 967
- Bibliographic source:
- In Russian. Gig. Trud. Prof. Zabol. 4:26-30.
Materials and methods
- Principles of method if other than guideline:
- no details on method given
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylamine
- EC Number:
- 200-875-0
- EC Name:
- Trimethylamine
- Cas Number:
- 75-50-3
- Molecular formula:
- C3H9N
- IUPAC Name:
- N,N-dimethylmethanamine
- Details on test material:
- CAS 75-50-3 (trimethylamine), purity not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- seven months
- Frequency of treatment:
- 5 hours per day
Doses / concentrationsopen allclose all
- Dose / conc.:
- 25 mg/m³ air
- Remarks:
- 25 mg/m³ (= 0.025 mg/L = 10 ppm)
- Dose / conc.:
- 75 mg/m³ air
- Remarks:
- 75 mg/m³ (= 0.075 mg/L = 31 ppm)
- No. of animals per sex per dose:
- Groups of 12 rats (sex not specified)
- Control animals:
- yes, concurrent no treatment
Examinations
- Observations and examinations performed and frequency:
- no details given
- Sacrifice and pathology:
- no details given
- Other examinations:
- no details given
- Statistics:
- no details given
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- The animals were irritated and aggressive during the first 3-4 weeks of exposure. Diarrhoea was observed 20-30 minutes after the start of exposure and ceased after 2-3 hours. Beginning from the second month of exposure, the feces of the animals normalised, and their behaviour did not differ from that of the controls.
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- Body weight did not show any differences between control and treated animals.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Protein spectrum of the blood did not show any differences between control and treated animals.
Investigation of the leukocyte formula demonstrated a reduction of the lymphocyte count, accompanied by a relative neutrophilia in the 75 mg/m³ (31 ppm) group from the fourth month of exposure. - Clinical biochemistry findings:
- not specified
- Description (incidence and severity):
- Detoxifying function of the liver did not show any differences between control and treated animals.
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- Measurement of the weight ratios of the internal organs demonstrated an increased weight of the adrenals.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Pathological examination demonstrated bronchopneumonia and haemorrhage into the lung tissues, with destruction of the interalveolar septa, signs of passive hyperaemia, and isolated haemorrhages in the liver, kidneys, and spleen in the 75 mg/m³ (31 ppm) group. Analogous, though less marked, changes were also observed in the animals of the 25 mg/m³ (10 ppm) group.
Morphological changes in the lung, liver, kidneys, spleen at 31 ppm with similar, less marked changes at 10 ppm. - Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Pathological examination demonstrated bronchopneumonia and haemorrhage into the lung tissues, with destruction of the interalveolar septa, signs of passive hyperaemia, and isolated haemorrhages in the liver, kidneys, and spleen in the 75 mg/m³ (31 ppm) group. Analogous, though less marked, changes were also observed in the animals of the 25 mg/m³ (10 ppm) group.
Morphological changes in the lung, liver, kidneys, spleen at 31 ppm with similar, less marked changes at 10 ppm. - Histopathological findings: neoplastic:
- not specified
- Details on results:
- The animals were irritated and aggressive during the first 3-4 weeks of exposure. Diarrhoea was observed 20-30 minutes after the start of exposure and ceased after 2-3 hours. Beginning from the second month of exposure, the feces of the animals normalised, and their behaviour did not differ from that of the controls.
Body weight, protein spectrum of the blood and detoxifying function of the liver did not show any differences between control and treated animals.
Measurement of the weight ratios of the internal organs demonstrated an increased weight of the adrenals.
Investigation of the leukocyte formula demonstrated a reduction of the lymphocyte count, accompanied by a relative neutrophilia in the 75 mg/m³ (31 ppm) group from the fourth month of exposure.
Pathological examination demonstrated bronchopneumonia and haemorrhage into the lung tissues, with destruction of the interalveolar septa, signs of passive hyperaemia, and isolated haemorrhages in the liver, kidneys, and spleen in the 75 mg/m³ (31 ppm) group. Analogous, though less marked, changes were also observed in the animals of the 25 mg/m³ (10 ppm) group.
Morphological changes in the lung, liver, kidneys, spleen at 31 ppm with similar, less marked changes at 10 ppm.
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 25 mg/m³ air
- Sex:
- not specified
- Basis for effect level:
- other: no details on basis given
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- LOAEC = 0.025 mg/L air
- Executive summary:
Rotenberg and Mashbits performed in 1967 a subchronic test on 12 rats with trimethylamine by the route of inhalation. The test duration was 7 months, the substance was administered 5 hours per day at concentrations of 0.025 and 0.075 mg/L. The animals were irritated and aggressive during the first 3-4 weeks of exposure. Diarrhoea was observed 20 – 30 minutes after the start of exposure and ceased after 2-3 hours. Beginning from the second month of exposure, the faeces of the animals normalized, and their behaviour did not differ from that of the controls. Body weight, protein spectrum of the blood and detoxifying function of the liver did not show any differences between control and treated animals. Measurement of the weight ratios of the internal organs demonstrated an increased weight of the adrenals. Investigation of the leukocyte formula demonstrated a reduction of the lymphocyte count, accompanied by a relative neutrophilia in the 75mg/m³ (31 ppm) group from the fourth month of exposure. Pathological examination demonstrated bronchopneumonia and haemorrhage into the lung tissues, with destruction of the interalveolar septa, signs of passive hyperaemia, and isolated haemorrhages in the liver, kidneys, and spleen in the 75 mg/m3 (31 ppm) group. Analogous, though less marked, changes were also observed in the animals of the 25 mg/m³ (10 ppm) group. Morphological changes in the lung, kidneys, spleen at 31 ppm with similar, less marked changes at 10 ppm.
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