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Diss Factsheets
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EC number: 200-875-0 | CAS number: 75-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Regarding transport and distribution, information about soil adsorption of trimethylamine as well as a calculation for the Henry´s Law constant of the substance is available. Trimethylamine is not suspected to adsorb significantly to suspended solids and sediments due to the estimated Koc values of 6 (von Oepen, 1991) as well as values of 4 and 29 (Lyman, W.C., 1982 - Handbook of Chemical Property Estimation Methods; Pomona College Medicinal Project - Log P database, Swann et al., 1984, and The Arizona Data Base). A high mobility in soil is expected for the substance. For the uncharged form of trimethylamine a Koc of 7.32 (logKoc of 0.86) was calculated with the MCI method of computer program KOCWIN2.00 of EPISuite v4.11 (Chemservice S.A., 2018). The adsorption of trimethylamine (and other amines) by Montmorillonite and Kaolinite is consistent with control by electrostatic attraction and van der Waals forces. In clays and Flax Pont sediments the adsorption of amines can be a reversible process (Wang, X.C. and Lee, C., 1993).
At 25 °C a Henry´s Law Constant of 3.7 Pa m3/mol was calculated. However, the model does not consider the ionic form of the molecule at environmental conditions; hence, distribution into air may be overestimated (Chemservice S.A., 2018). A SRC recommended value of 0.000104 atm m3/mol (corresponding to 10.5 pa m3/mol) was additionally reported by Hine (1975). Based on a weight-of-evidence approach by the available data, the substance is assessed to slowly evaporate into the atmophere from the water surface. Distribution modelling was performed using the estimation tools Mackay (Level I) and the Fugacity Model (Level III; EPISuite v4.11). Over time the substance will preferentially distribute into the compartments water (91.5%) and air (8.5%). As the substance ionises at environmetally relevant pH, the distribution into water may still be underestimated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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