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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 14 1981 to April 28 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with GLP; methodology considered similar to then-current standardized guidelines although no analytical verification of test compound concentrations is reported.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- skin abraded prior to substance application
- Principles of method if other than guideline:
- Product was administered once to freshly abraded rabbit skin sites and allowed to remain for 24 hours.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): Tetrabromobisphenol-A
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- InChl (if other than submission substance): N/A
- Structural formula attached as image file (if other than submission substance): see Fig. N/A
- Substance type: Monoconstituent
- Physical state: Solid, white powder
- Analytical purity: Not reported
- Impurities (identity and concentrations): Not reported
- Composition of test material, percentage of components: Not reported
- Isomers composition: Not reported
- Purity test date: Not reported
- Lot/batch No.: R6/FD2
- Expiration date of the lot/batch: Not reported
- Radiochemical purity (if radiolabelling): N/A
- Specific activity (if radiolabelling): N/A
- Locations of the label (if radiolabelling): N/A
- Expiration date of radiochemical substance (if radiolabelling): N/A
- Stability under test conditions: There was no apparent change in the physical state of the test article during administration
- Storage condition of test material: N/A
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Perfection Breeders. Inc.
- Age at study initiation: Not reported
- Weight at study initiation: 2-3 kg
- Fasting period before study: Not reported
- Housing: Individually in appropriately-sized cages
- Diet (e.g. ad libitum): Wayne Rabbit Ration, ad libitum
- Water (e.g. ad libitum): Tap water fit for human consumption, ad libitum
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 72 +/- 5F
- Humidity (%): AMbient
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 10hrs light: 14hrs dark
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Slightly moistened with physiological saline to produce a paste
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 10% of dorsal body surface
- % coverage: 10% of dorsal body surface
- Type of wrap if used: Layer of gauze covered with a rubber dam
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 g/kg
- Concentration (if solution): N/A
- Constant volume or concentration used: Yes
- For solids, paste formed: Yes
VEHICLE
- Amount(s) applied (volume or weight with unit): Not reported - Duration of exposure:
- 24hrs
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- Five males and five females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 2 and 4 hours after exposure period, and then twice daily for a total of 14 days
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight - Statistics:
- Average and standard deviation calculations
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 other: g/kg
- Mortality:
- None
- Clinical signs:
- other: Slight erythema and edema were observed in one of the ten rabbits on day 1
- Gross pathology:
- No visible lesion in any of the rabbits
- Other findings:
- None
Any other information on results incl. tables
Table 1: Mean rabbit body weights (with S.D. and N) following 24hr dermal exposure to Tetrabromobisphenol-A
|
Day 0 weight |
Day 7 weight |
Day 14 weight |
||||||
Sex |
Avg (g) |
S.D. |
N |
Avg (g) |
S.D. |
N |
Avg (g) |
S.D. |
N |
M |
2488 |
70.38 |
5 |
2804 |
174.04 |
5 |
2784 |
259.36 |
5 |
F |
2438 |
201.79 |
5 |
2592 |
43187 |
5 |
2643 |
389.37 |
5 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 in rabbits for Tetrabromobisphenol-A is greater than 2 g/kg bw
- Executive summary:
In an acute dermal toxicity study conducted to GLP, tetrabromobisphenol-A, Lot #R6/PD2, was applied at 2 g/kg of body weight to ten rabbits (five males and five females). The test article was administered directly on the skin which was abraded within two hours prior to application. All animals survived the 2 g/kg dose for the fourteen day observation period. Slight erythema and edema were observed in one of the ten rabbits on Day 1. No other signs were visible during the fourteen day study. Terminal necropsy revealed no visible lesions in any rabbits on study.
The acute dermal LD50 in rabbits for Tetrabromobisphenol-A is greater than 2 g/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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