Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 203-896-3 | CAS number: 111-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via inhalation route
- Dose descriptor:
- NOAEC
- 99 mg/m³
Additional information
There were no significant detectable male/female fertility effects at any of the exposure levels tested as judged by mating efficiency, pregnancy rates, number of live implants or pre- or postimplantation loss. The fertility NOAEC was the highest concentration tested, 104 mg/m3 air. There was a slightly statistically significant reduction in mean body weights of the females during exposure weeks 2 and 3. Because this effect was observed prior to mating, the exposure concentration of 104 mg/m3 could be considered a maternal systemic LOAEC with no relation to fertility effects.
Short description of key information:
There were no significant detectable male/female fertility effects at any of the exposure levels tested as judged by mating efficiency, pregnancy rates, number of live implants or pre- or postimplantation loss. The fertility NOAEC was the highest concentration tested, 104 mg/m3 air. There was a slightly statistically significant reduction in mean body weights of the females during exposure weeks 2 and 3. Because this effect was observed prior to mating, the exposure concentration of 104 mg/m3 could be considered a maternal systemic LOAEC with no relation to fertility effects.
Effects on developmental toxicity
Description of key information
Treatment with adiponitrile did not produce a teratogenic response in OECD 414 study.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 80 mg/kg bw/day
Additional information
Treatment with adiponitrile did not produce a teratogenic response when administered orally to pregnant Charles River COBS CD rats at a dosage level of 80 mg/kg/day or less. No teratogenic response was noted in pilot study.
Justification for classification or non-classification
No reproductive effects were noted for adiponitrile.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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