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EC number: 203-896-3 | CAS number: 111-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 20DEC1979 08FEB1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Method is described, no numerical value resulted from the testing performed. Quality issues are reported on the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Five groups of five male and five female Sprague-Dawley rats per group were each exposed for six hours to different atmospheric concentrations of adiponitrile (ADN). Analytical concentrations of ADN in the chamber ranged from 0.79 to 2.18 mg/l in air.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Adiponitrile
- EC Number:
- 203-896-3
- EC Name:
- Adiponitrile
- Cas Number:
- 111-69-3
- Molecular formula:
- C6H8N2
- IUPAC Name:
- hexanedinitrile
- Details on test material:
- - Name of test material (as cited in study report): Adiponitrile
- Physical state: Clear liquid
- Analytical purity: 99.3%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Sprague-Dawley rats were obtained from the Charles River Breeding Laboratories. Test animals were held and observed in quarantine for seven days prior to release for the study. At the time of exposure , aninals were 42-54 days of age with males weighing 200-280 grams and females 150-202 grams. Each rat was uniquely identified by eartag and bar-coded cage card.
Animals were individually housed in suspended stainless steel wire mesh cages (23 cm x 23 cm x 21 cm) and given Purina Laboratory Standard Rodent Chow® (5001)2 and tap water (St. Louis City, MO) ad libitum except during the exposure period. Animal rooms were routinely maintained at 70-740F and 35-65% relative humidity with a 12-hour light/dark cycle.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Duration of exposure:
- 6 h
- Concentrations:
- 0.79 mg/L
1.00 mg/L
1.41 mg/L
1.56 mg/L
2.18 mg/L - No. of animals per sex per dose:
- 5 males and 5 females per dose.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.18 mg/L air (analytical)
- Exp. duration:
- 6 h
Applicant's summary and conclusion
- Conclusions:
- The presence of chromorhinorrhea, hemorrage of the lung and gray appearance of the lung are indications that ADN is a respiratory irritant. Only six male rats out of 50 died during the study with concentrations from 0.79 to 2.18 mg/L, making it impossible to calculate a LC50.
- Executive summary:
LC50 > 2.18 mg/L. Test substance is a respiratory irritant (used for classification)
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