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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Unknow purity

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
12.5% ​​suspension in sesame oil

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
vegetable oil
Remarks:
sesame oil
Doses:
2 times 5000 mg/kg bw were dosed to each rat via gavage within 1 hour
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 > 10,000 mg/kg
Executive summary:

No rats died during the study. Passivity and diarrhea were observed after the dosing. Faeces and urine were stained red. The discoloration of the feces was observed up to 7 days after application. The occurrence of reddish skin discoloration after 24 hours was occasionally observed up to the end of study.

The behavior and body weight development were normal in the 14-day follow-up period.

The sections of the killed animals after the experiments were macroscopically inconspicuous