Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: ETAD Method (Version: 12th January 2005)
Deviations:
no
Principles of method if other than guideline:
5 mg test substance were suspended in 30 mL water (bi dest.) and shaken at 400rpm for 2 hours at 30°C. Then shaking was continued at ambient temperature (23-24°C) for 70 hours followed by filtration through a 0.05µm filter. The resulting clear solution was measured by UV-vis spectrometry at  = 514nm and concentrations calculated using Lambert-Beer rule.
GLP compliance:
no
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Water solubility
Water solubility:
3.3 µg/L
Temp.:
23 °C
pH:
ca. 7

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
Insoluble
Executive summary:

The water solubility of the test substance Pigment Red 3 was determined according to the method agreed upon at the ”Analytical Experts Meeting” of ETAD (Basel) on January 12, 2005.

The test substance was shaken with water for 2 hours at 30°C, then for 70 hours at 23-24°C. After filtration, the solubility was tested by use of a UV-vis spectrometer. The determination was repeated three times.

The solubility of Pigment Red 3 in water at 23-24°C was determined to be 3.3µg/L.