Registration Dossier
Registration Dossier
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EC number: 204-984-4 | CAS number: 130-26-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Considering that approximately 25% of a 750 mg oral dose of Clioquinol is excreted in the urine over 72 h, it can be considered that the chemical is likely to have low bio-accumulation potential in humans. Dermal application also suggests less than 25% excretion of the chemical via the urinary route
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
There are reports which suggest that professional soccer players were treated with 500mg of Clioquinol for an unspecified period. The individuals receiving Clioquinol had reduced incidence of diarrhea and no adverse effects were reported. Studies of 750 mg and 1000 mg of Clioquinol were also reported to have efficacy in the prevention of diarrhea and no adverse events were noted.Thus, it can be concluded that sinceClioquinolis likely to have low bio-accumulation potential in humans, no toxic effects were exhibited upon oral administration of the chemical for longer durations.
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