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Diss Factsheets
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EC number: 216-133-4 | CAS number: 1506-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 18 June 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report is a historical overview of the conditions of workers with regard to respiratory sensitisation.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The olfactive quality control of Tonalid is a repeated exposure to Tonalid. The history of the staff of quality assurance has been reviewed. No specific test protocol has been developed prior to the assessment. However, the olfactive quality control procedure at the Quality Assurance (QA) department of PFW Aroma Chemicals BV has been described in detail as part of the ISO 9001 certification. PFW has been ISO 9001 certified and keeps record of the olfactive quality control.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
- EC Number:
- 216-133-4
- EC Name:
- 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
- Cas Number:
- 1506-02-1
- Molecular formula:
- C18H26O
- IUPAC Name:
- 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
Constituent 1
Test animals
- Species:
- human
- Sex:
- male/female
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- 100% AHTN
- Details on study design:
- Workers at the quality assurance department conduct olfactive quality controls of pure (100%) AHTN (CAS 1506-02-1). Liquid samples, which are at elevated temperatures are cooled, solidified and ground. Powder samples are only ground. Olfactive control takes place at the head space of the sample.
Results and discussion
- Results:
- No sensory irritation of the airways and no respiratory reactions like asthma, rhinitis and alveolites were reported over a period of more than two decades.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- and not a respiratory irritant
- Conclusions:
- Based on the human practical experience, it is concluded that AHTN is not a respiratory irritant or sensitiser.
- Executive summary:
Respiratory irritation and sensitisation have been assessed on the basis of occupational exposure of the quality assurance staff to pure AHTN during the olfactive quality control of Tonalid.
No adverse respiratory responses to AHTN have been reported. It is concluded that AHTN is not a respiratory irritant or sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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