Registration Dossier
Registration Dossier
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EC number: 931-740-0 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of the substance to Desmodesmus subspicatus was determined by using the OECD guideline method 201 in a compliance with Good Laboratory Practice. As the substance is a UVCB- substance, there are differences in the partitioning behavior and water solubility between the constituents. Therefore water accommodated fractions (WAFs) were prepared, and the exposure was expressed as the loading rates (mass to volume ratio of the mixture to medium) after 72 hours exposure. The specific growth rate was used as the endpoint measurement.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 27.17 mg/L
- EC10 or NOEC for freshwater algae:
- 10.26 mg/L
Additional information
The acute toxicity of the substance toD. subspicatuswas determined by using the OECD guideline method 201 in a compliance with Good Laboratory Practice. As the substance is a UVCB- substance, there are differences in the partitioning behavior and water solubility between the constituents. Therefore, water accommodated fractions (WAFs) were prepared, and the exposure was expressed as the loading rates (mass to volume ratio of the mixture to medium) after 72 hours exposure. The WAF loading rates used were the following: 6.25 mg/L, 12.50 mg/L, 25.00 mg/L, 50.00 mg/L and 100.00 mg/L.
The inhibition of growth was used as an endpoint measurement, expressed as the logarithmic increase in biomass. In addition, the effective exposure loading rates were expressed based on the measured biomass yield. The substance showed higher toxicity response for the biomass yield than for the average specific growth rate. It must be pointed out that toxicity values calculated by using these two response variables are not comparable. Average specific growth rate is considered scientifically more preferable for estimating of toxicity.
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