Registration Dossier
Registration Dossier
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EC number: 403-590-1 | CAS number: 104815-18-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: See 'Remark'
- Remarks:
- All information in this endpoint has been provided by the ECHA using the 12-year rule, this is data not owned by the registrant. The reliability is assumed to be at level 2. Therefore the following reliability statement can be used: Study conducted in accordance with generally accepted scientific principles, possibly with incorect reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- other: All information in this endpoint has been provided by the ECHA using the 12-year rule, this is data not owned by the registrant.
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- Principles of method if other than guideline:
- Information from migrated NONS file, as per inquiry number 06-0000021057-76-0000, permission to refer granted by ECHA.
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 403-590-1
- EC Name:
- -
- Cas Number:
- 104815-18-1
- Molecular formula:
- C46 H32 Cl2 Fe N7 O6
- IUPAC Name:
- iron(3+) ammonium bis(1-[2-(5-chloro-2-oxidophenyl)diazen-1-yl]-3-(phenylcarbamoyl)naphthalen-2-olate)
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: none
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3.37 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: 0 mg/L; Number of animals: 5; Number of deaths: 0
Male: 3.37 mg/L; Number of animals: 5; Number of deaths: 0
Female: 0 mg/L; Number of animals: 5; Number of deaths: 0
Female: 3.37 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Signs of exposure were confined to staining of the skin, fur and tail by the substance. There was a small reduction in food and water consumption in male exposed rats on day 1.
- Gross pathology:
- Effects on organs:
The lungs of all treated animals were coloured greyish due to the substance. Lung to bodyweight ratios were unaffected. No treatment - related changes were found in tissues examined microscopically(lungs, liver, kidneys).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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