Registration Dossier
Registration Dossier
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EC number: 827-581-0 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus originates from a clone breeding of the German Federal Environmental Agency, department V 3.2, Berlin
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Test temperature:
- 20.6 to 21.4°C
- pH:
- 7.5-8.7
- Dissolved oxygen:
- 7.59 to 8.37 mg/L
- Nominal and measured concentrations:
- Nominal= 6.25, 12.5, 25,50,100, 200
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14.08 mg/L
- Nominal / measured:
- nominal
- Remarks on result:
- other: 98% CL
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.25 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 12.15 mg/L
- Nominal / measured:
- nominal
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study performed to OECD 202, SLMI was found to have an EC50 (48h) of 14.1 mg/L
- Executive summary:
In a study performed to OECD 202, SLMI was found to have an EC50 (48h) of 14.1 mg/L
Reference
The recovery rates ranged from 97.3% to 120.0%. The highest decrease of the test concentration was -1.5%. According to the analytical results SLMI was stable during the test course.
Description of key information
In a study performed to EPA OPPTS 850.1010 (equivalent to OECD 202), SCMI was found to have an EC50 of 257.86 mg/l (nominal concentration)
In a study performed in accordance with OECD 202, the read-across analogue SLMI was found to have an EC50 (48h) of 14.1 mg/L
SCMI is less toxic to aquatic invertebrates than SLMI due to the greater proportion of shorter C8 and C10 alkyl chain lengths in the mixture.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 257.9 mg/L
Additional information
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